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Appl. Sci. 2018, 8(4), 492; doi:10.3390/app8040492

Matrix-Assisted Laser Desorption Ionization Mass Spectrometry of Compounds Containing Carboxyl Groups Using CdTe and CuO Nanoparticles

1
Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo 192-0379, Japan
2
Department of Applied Chemistry, Graduate School of Science and Engineering, Toyo University, 2100 Kujirai, Kawagoe 350-8585, Japan
3
Bio-Nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe 350-8585, Japan
*
Author to whom correspondence should be addressed.
Received: 14 February 2018 / Revised: 23 March 2018 / Accepted: 23 March 2018 / Published: 26 March 2018
(This article belongs to the Special Issue Photoionization Mass Spectrometry)
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Abstract

Matrix-assisted laser desorption ionization mass spectrometry of compounds containing carboxyl groups was carried out by using semiconductor nanoparticles (CdTe and CuO) as the matrix. Salicylic acid (Sal), glucuronic acid (Glu), ibuprofen (Ibu), and tyrosine (Tyr) were ionized as deprotonated species (carboxylate anions) by using electrons ejected from CdTe after the photoexcitation. When CuO was used as the matrix, the peak intensity of Tyr became high compared with that obtained with CdTe. Measurements of model peptides, angiotensin II (AngII) and substance P (SubP), were also carried out but the obtained peak intensities were very low. In order to explain this result, the interaction between CdTe and AngII was confirmed by diffuse reflectance spectroscopy. The results suggest that electrostatic binding between semiconductor nanoparticles and AngII prevented the efficient desorption of AngII into the gas phase. View Full-Text
Keywords: MALDI; semiconductor; nanoparticles; carboxyl group MALDI; semiconductor; nanoparticles; carboxyl group
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Sakurai, M.; Sato, T.; Xu, J.; Sato, S.; Fujino, T. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry of Compounds Containing Carboxyl Groups Using CdTe and CuO Nanoparticles. Appl. Sci. 2018, 8, 492.

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