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Appl. Sci. 2018, 8(2), 286; https://doi.org/10.3390/app8020286

Riding the Plane Wave: Considerations for In Vivo Study Designs Employing High Frame Rate Ultrasound

1
Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada
2
Schlegel-University of Waterloo Research Institute for Aging, Waterloo, ON N2J 0E2, Canada
3
Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada
*
Author to whom correspondence should be addressed.
Received: 15 January 2018 / Revised: 9 February 2018 / Accepted: 13 February 2018 / Published: 14 February 2018
(This article belongs to the Special Issue Ultrafast Ultrasound Imaging)
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Abstract

Advancements in diagnostic ultrasound have allowed for a rapid expansion of the quantity and quality of non-invasive information that clinical researchers can acquire from cardiovascular physiology. The recent emergence of high frame rate ultrasound (HiFRUS) is the next step in the quantification of complex blood flow behavior, offering angle-independent, high temporal resolution data in normal physiology and clinical cases. While there are various HiFRUS methods that have been tested and validated in simulations and in complex flow phantoms, there is a need to expand the field into more rigorous in vivo testing for clinical relevance. In this tutorial, we briefly outline the major advances in HiFRUS, and discuss practical considerations of participant preparation, experimental design, and human measurement, while also providing an example of how these frameworks can be immediately applied to in vivo research questions. The considerations put forward in this paper aim to set a realistic framework for research labs which use HiFRUS to commence the collection of human data for basic science, as well as for preliminary clinical research questions. View Full-Text
Keywords: high frame rate ultrasound; ultrafast ultrasound; human studies; neurovascular control high frame rate ultrasound; ultrafast ultrasound; human studies; neurovascular control
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Au, J.S.; Hughson, R.L.; Yu, A.C.H. Riding the Plane Wave: Considerations for In Vivo Study Designs Employing High Frame Rate Ultrasound. Appl. Sci. 2018, 8, 286.

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