Next Article in Journal
A Feature-Based Structural Measure: An Image Similarity Measure for Face Recognition
Previous Article in Journal
Comparative Performance of Thermoacoustic Heat Exchangers with Different Pore Geometries in Oscillatory Flow. Implementation of Experimental Techniques
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Appl. Sci. 2017, 7(8), 785; doi:10.3390/app7080785

An Efficient Synthesis of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents

1
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
2
Department of Chemistry, Faculty of Dentistry, October University for Modern Science & Arts, Giza 12613, Egypt
3
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Received: 22 July 2017 / Revised: 28 July 2017 / Accepted: 31 July 2017 / Published: 3 August 2017
(This article belongs to the Section Chemistry)
View Full-Text   |   Download PDF [1401 KB, uploaded 3 August 2017]   |  

Abstract

A new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl-1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or ethyl acetoacetate and an excess of ammonium acetate under reflux in acetic acid. Similarly, two novel bipyridine derivatives were prepared by the above reaction using terephthaldehyde in lieu of benzaldehyde derivatives. In addition, a series of 1,2,4-triazolo[4,3-a]pyrimidines was synthesized by a reaction of 6-(pyrazol-3-yl)pyrimidine-2-thione with a number of hydrazonoyl chlorides in dioxane and in the presence of triethylamine. The structure of the produced compounds was established by elemental analyses and spectral methods, and the mechanisms of their formation was discussed. Furthermore, the pyrazolyl-pyridine derivatives were tested as anticancer agents and the results obtained showed that some of them revealed high activity against human hepatocellular carcinoma (HEPG2) cell lines. View Full-Text
Keywords: pyrazoles; pyridines; multicomponent reactions; pyrazolyl-pyridines; antitumor activity pyrazoles; pyridines; multicomponent reactions; pyrazolyl-pyridines; antitumor activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Abdallah, M.A.; Gomha, S.M.; Abbas, I.M.; Kazem, M.S.H.; Alterary, S.S.; Mabkhot, Y.N. An Efficient Synthesis of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents. Appl. Sci. 2017, 7, 785.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Appl. Sci. EISSN 2076-3417 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top