RETRACTED: A Si-αTCP Scaffold for Biomedical Applications: An Experimental Study Using the Rabbit Tibia Model
Abstract
:1. Introduction
2. Materials and Methods
2.1. Preparation and Characterization of the Si-TCP Scaffolds
2.2. Animals and Surgical Procedure
2.3. Histological and Histomorphometric Analysis
2.4. Statistical Analysis
3. Results
3.1. Implant Characterization
3.2. In Vivo Implant Characterization
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Test Group | Control | |||||||
---|---|---|---|---|---|---|---|---|
% | 15 Days | 30 Days | 60 Days | p Values * | p Values ** | 15 Days | 30 Days | 60 Days |
BIC | 54.34 ± 0.32 (54.34) | 60.33 ± 0.13 (60.33) | 68.32 ± 1.21 ** (68.32) * | 0.014 | 0.038 | 0.00 ± 0.0 | 0.00 ± 0.0 | 0.00 ± 0.0 |
New Bone | 48.83 ± 1.32 (48.83) | 52.26 ± 0.95 * (52.26) | 60.11 ± 2.01 ** (60.11) * | 0.028 | 0.011 | 26.07 ± 0.05 (26.07) | 26.26 ± 0.43 * (26.26) | 27.10 ± 0.32 ** (27.10) * |
Residual | 32.18 ± 1.75 (32.18) | 29.94 ± 13 * (29.94) | 23.75 ± 0.85 (23.75) | 0.037 | 0.029 | 0.00 ± 0.0 | 0.00 ± 0.0 | 0.00 ± 0.0 |
Defect Closure | 58.63 ± 1.03 (58.63) | 66.24 ± 4.06 (66.24) | 79.01 ± 94 ** (79.01) * | 0.015 | 0.014 | 10.87 ± 0.23 (10.87) | 25.56 ± 0.43 * (25.56) | 28.12 ± 0.32 ** (28.12) * |
Resorption Rate | 35.93 ± 0.32 (25.93) | 42.14 ± 1.63 (32.14) | 53.13 ± 2.47 (40.13) * | 0.023 | 0.026 | 0.00 ± 0.0 | 0.00 ± 0.0 | 0.00 ± 0.0 |
Connective Tissue | 18.37 ± 1.20 (18.37) | 17.30 ± 3.01 (17.30) | 16.14 ± 1.33 (16.14) | 0.036 | 0.022 | 0.00 ± 0.0 | 0.00 ± 0.0 | 0.00 ± 0.0 |
(wt %) | O | Ca | P | Si | Ca/P Ratio |
---|---|---|---|---|---|
Implant/Scaffold | |||||
15 days | 44.73 ± 0.12 (44.73) | 35.01 ± 0.25 (32.01) | 20.25 ± 0.46 (20.25) | 0.11 ± 1.62 (0.11) | 1.74 ± 0.86 (1.74) |
30 days | 45.43 ± 0.13 (45.43) | 32.12 ± 0.24 (32.14) | 22.36 ± 0.43 (22.36) | 0.09 ± 1.83 (0.09) | 1.44 ± 0.84 (1.44) |
60 days | 48.47 ± 0.12 (48.47) | 29.62 ± 0.26 (29.62) | 21.84 ± 0.35 (21.84) | 0.07 ± 1.82 (0.07) | 1.36 ± 0.76 (1.36) |
Bone Interfase | |||||
15 days | 50.68 ± 0.11 (50.68) | 32.95 ± 0.31 (32.95) | 16.32 ± 0.53 (16.32) | 0.05 ± 1.63 (0.05) | 2.02 ± 0.95 (2.02) |
30 days | 55.88 ± 0.10 (55.88) | 30.23 ± 0.29 (30.23) | 13.85 ± 0.54 (13.85) | 0.04 ± 1.33 (0.04) | 2.18 ± 0.84 (2.18) |
60 days | 59.15 ± 0.12 (59.15) | 28.62 ± 0.32 (28.62) | 12.21 ± 0.75 (12.21) | 0.02 ± 1.25 (0.02) | 2.34 ± 0.96 (2.34) |
New bone | |||||
15 days | 59.69 ± 0.15 (59.69) | 26.78 ± 0.16 (26.78) | 13.5 ± 0.62 (13.50) | 0.02 ± 1.63 (0.02) | 1.98 ± 0.83 (1.98) |
30 days | 60.56 ± 0.09 (60.56) | 25.42 ± 0.24 (25.42) | 14.01 ± 0.53 (14.01) | 0.01 ± 1.71 (0.01) | 1.81 ± 0.91 (1.81) |
60 days | 63.38 ± 0.09 (63.38) | 24.36 ± 0.15 (24.36) | 12.25 ± 0.74 (12.25) | 0.01 ± 1.03 (0.01) | 1.98 ± 0.97 (1.98) |
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De Aza, P.N.; Rodríguez, M.A.; Gehrke, S.A.; Maté-Sánchez de Val, J.E.; Calvo-Guirado, J.L. RETRACTED: A Si-αTCP Scaffold for Biomedical Applications: An Experimental Study Using the Rabbit Tibia Model. Appl. Sci. 2017, 7, 706. https://doi.org/10.3390/app7070706
De Aza PN, Rodríguez MA, Gehrke SA, Maté-Sánchez de Val JE, Calvo-Guirado JL. RETRACTED: A Si-αTCP Scaffold for Biomedical Applications: An Experimental Study Using the Rabbit Tibia Model. Applied Sciences. 2017; 7(7):706. https://doi.org/10.3390/app7070706
Chicago/Turabian StyleDe Aza, Piedad N., Miguel A. Rodríguez, Sergio A. Gehrke, José E. Maté-Sánchez de Val, and Jose L. Calvo-Guirado. 2017. "RETRACTED: A Si-αTCP Scaffold for Biomedical Applications: An Experimental Study Using the Rabbit Tibia Model" Applied Sciences 7, no. 7: 706. https://doi.org/10.3390/app7070706