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Appl. Sci. 2017, 7(4), 382; doi:10.3390/app7040382

Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain

1
Department of Medical Physics and Biomedical Engineering, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany
2
Clinical Sensoring and Monitoring, Anesthesiology and Intensive Care Medicine, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany
*
Author to whom correspondence should be addressed.
Received: 20 January 2017 / Revised: 20 March 2017 / Accepted: 4 April 2017 / Published: 11 April 2017
(This article belongs to the Special Issue Development and Application of Optical Coherence Tomography (OCT))
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Abstract

In spectral domain optical coherence tomography (SD-OCT), any transverse motion component of a detected obliquely moving sample results in a nonlinear relationship between the Doppler phase shift and the axial sample velocity restricting phase-resolved Doppler OCT (PR-DOCT). The size of the deviation from the linear relation depends on the amount of the transverse velocity component, given by the Doppler angle, and the height of the absolute sample velocity. Especially for very small Doppler angles between the horizontal and flow direction, and high flow velocities, the detected Doppler phase shift approaches a limiting value, making an unambiguous measurement of the axial sample velocity by PR-DOCT impossible. To circumvent this limitation, we propose a new method for resonant Doppler flow quantification in spectral domain OCT, where the scanner movement velocity is matched with the transverse velocity component of the sample motion similar to a tracking shot, where the camera is moved with respect to the sample. Consequently, the influence of the transverse velocity component of the tracked moving particles on the Doppler phase shift is negligible and the linear relation between the phase shift and the axial velocity component can be considered for flow velocity calculations. The proposed method is verified using flow phantoms on the basis of 1% Intralipid solution and diluted human blood. View Full-Text
Keywords: optical coherence tomography; phase-resolved Doppler analysis; flow measurement; oblique sample motion; non-invasive imaging technique; random scattering sample optical coherence tomography; phase-resolved Doppler analysis; flow measurement; oblique sample motion; non-invasive imaging technique; random scattering sample
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Walther, J.; Koch, E. Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain. Appl. Sci. 2017, 7, 382.

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