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Appl. Sci. 2017, 7(12), 1275; doi:10.3390/app7121275

Effects of Low Intensity Continuous Ultrasound (LICU) on Mouse Pancreatic Tumor Explants

1
Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
2
Institute of Physics and Information Technologies, Group of Ultrasonic Resonators, CSIC, Serrano 144, 28006 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 25 October 2017 / Revised: 29 November 2017 / Accepted: 4 December 2017 / Published: 8 December 2017
(This article belongs to the Section Acoustics)
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Abstract

This paper describes the effects of low intensity continuous ultrasound (LICU) on the inflammatory response of mouse pancreatic tumor explants. While there are many reports focusing on the application of low-intensity pulsed ultrasound (LIPUS) on cell cultures and tissues, the effects of continuous oscillations on biological tissues have never been investigated. Here we present an exploratory study of the effects induced by LICU on mouse pancreatic tumor explants. We show that LICU causes significant upregulation of IFN-γ, IL-1β, and TNF-α on tumor explants. No detectable effects were observed on tumor vasculature or collagen I deposition, while thermal and mechanical effects were not apparent. Tumor explants responded as a single unit to acoustic waves, with spatial pressure variations smaller than their size. View Full-Text
Keywords: low-intensity continuous ultrasound; bioeffects; inflammation; tumor; interferon-γ interleukins; tumor necrosis factor-α (TNF-α); collagen I; vasculature low-intensity continuous ultrasound; bioeffects; inflammation; tumor; interferon-γ interleukins; tumor necrosis factor-α (TNF-α); collagen I; vasculature
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bazou, D.; Maimon, N.; Munn, L.L.; Gonzalez, I. Effects of Low Intensity Continuous Ultrasound (LICU) on Mouse Pancreatic Tumor Explants. Appl. Sci. 2017, 7, 1275.

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