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Appl. Sci. 2016, 6(12), 411; doi:10.3390/app6120411

Tunable Degradation Rate and Favorable Bioactivity of Porous Calcium Sulfate Scaffolds by Introducing Nano-Hydroxyapatite

1
State Key Laboratory of High Performance Complex Manufacturing, the State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China
2
Health Management Center, Xiangya Hospital, Central South University, Changsha 410008, China
3
The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, the Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and Cancer Research Institute, Xiangya Hospital, Central South University, Changsha 410078, China
4
Motion System Injury Repair Research Center, Xiangya Hospital, Central South University, Changsha 410078, China
5
College of Chemistry, Xiangtan University, Xiangtan 411105, China
6
State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China
7
Hunan Farsoon High-Technology Co. Ltd., Changsha 410205, China
8
School of Humanities and Social Sciences, National University of Defense Technology, Changsha 410074, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Daniel X.B. Chen
Received: 17 October 2016 / Revised: 16 November 2016 / Accepted: 30 November 2016 / Published: 7 December 2016
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Abstract

The bone scaffolds should possess suitable physicochemical properties and osteogenic activities. In this study, porous calcium sulfate (CaSO4) scaffolds were fabricated successfully via selected laser sintering (SLS). Nano-hydroxyapatite (nHAp), a bioactive material with a low degradation rate, was introduced into CaSO4 scaffolds to overcome the overquick absorption. The results demonstrated that nHAp could not only control the degradation rate of scaffolds by adjusting their content, but also improve the pH environment by alleviating the acidification progress during the degradation of CaSO4 scaffolds. Moreover, the improved scaffolds were covered completely with the apatite spherulites in simulated body fluid (SBF), showing their favorable bioactivity. In addition, the compression strength and fracture toughness were distinctly enhanced, which could be ascribed to large specific area of nHAp and the corresponding stress transfer. View Full-Text
Keywords: selected laser sintering; porous scaffolds; degradation rate; pH environment; bioactivity selected laser sintering; porous scaffolds; degradation rate; pH environment; bioactivity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhou, J.; Yuan, F.; Peng, S.; Xie, H.; Wu, P.; Feng, P.; Gao, C.; Yang, Y.; Guo, W.; Lai, D.; Zhou, Z.; Zhu, X.; Shuai, C. Tunable Degradation Rate and Favorable Bioactivity of Porous Calcium Sulfate Scaffolds by Introducing Nano-Hydroxyapatite. Appl. Sci. 2016, 6, 411.

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