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Appl. Sci. 2016, 6(12), 392; doi:10.3390/app6120392

Photoacoustic Tomography Imaging of the Adult Zebrafish by Using Unfocused and Focused High-Frequency Ultrasound Transducers

Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China
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Author to whom correspondence should be addressed.
Academic Editor: Kohji Masuda
Received: 26 September 2016 / Revised: 18 November 2016 / Accepted: 23 November 2016 / Published: 30 November 2016
(This article belongs to the Special Issue Biomedical Ultrasound)
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Abstract

The zebrafish model provides an essential platform for the study of human diseases or disorders due to the possession of about 87% homologous genes with human. However, it is still very challenging to noninvasively visualize the structure and function of adult zebrafish based on available optical imaging techniques. In this study, photoacoustic tomography (PAT) was utilized for high-resolution imaging of adult zebrafish by using focused and unfocused high-frequency (10 MHz) ultrasound transducers. We examined and compared the imaging results from the two categories of transducers with in vivo experimental tests, in which we discovered that the unfocused transducer is able to identify the inner organs of adult zebrafish with higher contrast but limited regional resolution, whereas the findings from the focused transducer were with high resolution but limited regional contrast for the recovered inner organs. View Full-Text
Keywords: photoacoustic tomography (PAT); unfocused and focused transducers; zebrafish; contrast photoacoustic tomography (PAT); unfocused and focused transducers; zebrafish; contrast
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Liu, Y.; Li, D.; Yuan, Z. Photoacoustic Tomography Imaging of the Adult Zebrafish by Using Unfocused and Focused High-Frequency Ultrasound Transducers. Appl. Sci. 2016, 6, 392.

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