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Appl. Sci. 2015, 5(4), 1803-1836; doi:10.3390/app5041803

Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles

Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany
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Author to whom correspondence should be addressed.
Academic Editor: Miguel Yus Astiz
Received: 28 October 2015 / Revised: 4 December 2015 / Accepted: 8 December 2015 / Published: 16 December 2015

Abstract

Sequentially Pd-catalyzed processes are excellent entries to heterocycle synthesis. The broad mechanistic variety combined with often very mild reaction conditions allow the concatenation of elementary organic and organometallic steps to novel sequences in the sense of one-pot domino and multicomponent reactions. Given the numerous opportunities of alkyne coordination and their Pd-mediated transformations, alkynylation and carbometallation play a key role, both for purely organometallic sequences as well as in those processes that are intercepted by cyclocondensation. Pd-catalyzed aminations also find more and more entry into novel heterocycle syntheses based upon this theme. View Full-Text
Keywords: cyclization; cyclocondensation; domino reactions; molecular diversity; multicomponent reactions; synthetic methods cyclization; cyclocondensation; domino reactions; molecular diversity; multicomponent reactions; synthetic methods
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lessing, T.; Müller, T.J.J. Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles. Appl. Sci. 2015, 5, 1803-1836.

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