Next Article in Journal / Special Issue
Ion Acceleration by Short Chirped Laser Pulses
Previous Article in Journal
Acknowledgement to Reviewers of Applied Sciences in 2014
Previous Article in Special Issue
Laser-Driven Very High Energy Electron/Photon Beam Radiation Therapy in Conjunction with a Robotic System
Article Menu

Export Article

Open AccessReview
Appl. Sci. 2015, 5(1), 23-35; doi:10.3390/app5010023

Vibrational Microspectroscopy for Cancer Screening

1
DIT Centre for Radiation and Environmental Science, FOCAS Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
2
School of Physics, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
3
FOCAS Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Ken Ledingham
Received: 7 December 2014 / Revised: 5 February 2015 / Accepted: 10 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue Casting Light on Cancer Therapy)
View Full-Text   |   Download PDF [729 KB, uploaded 13 February 2015]   |  

Abstract

Vibrational spectroscopy analyses vibrations within a molecule and can be used to characterise a molecular structure. Raman spectroscopy is one of the vibrational spectroscopic techniques, in which incident radiation is used to induce vibrations in the molecules of a sample, and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Infrared (IR) spectroscopy is a complementary vibrational spectroscopic technique based on the absorption of IR radiation by the sample. Molecules absorb specific frequencies of the incident light which are characteristic of their structure. IR and Raman spectroscopy are sensitive to subtle biochemical changes occurring at the molecular level allowing spectral variations corresponding to disease onset to be detected. Over the past 15 years, there have been numerous reports demonstrating the potential of IR and Raman spectroscopy together with multivariate statistical analysis techniques for the detection of a variety of cancers including, breast, lung, brain, colon, oral, oesophageal, prostate and cervical cancer. This paper discusses the recent advances and the future perspectives in relation to cancer screening applications, focussing on cervical and oral cancer. View Full-Text
Keywords: optical diagnosis; lasers; Raman spectroscopy; FTIR spectroscopy; cervical cancer; oral cancer; screening; cytology optical diagnosis; lasers; Raman spectroscopy; FTIR spectroscopy; cervical cancer; oral cancer; screening; cytology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lyng, F.M.; Ramos, I.R.M.; Ibrahim, O.; Byrne, H.J. Vibrational Microspectroscopy for Cancer Screening. Appl. Sci. 2015, 5, 23-35.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Appl. Sci. EISSN 2076-3417 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top