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Appl. Sci. 2015, 5(1), 1-20; doi:10.3390/app5010001

Laser-Driven Very High Energy Electron/Photon Beam Radiation Therapy in Conjunction with a Robotic System

1
Center for Relativistic Laser Science, Institute for Basic Science (IBS), Gwangju 500-712, Korea
2
The Advanced Robotics Lab, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
3
Beijing National Laboratory of Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences (CAS), Beijing 100080, China
4
Key Laboratory for Laser Plasmas (MoE) and Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China
5
Department of Physics, Scottish Universities Physics Alliance, University of Strathclyde, Glasgow G4 0NG, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Ken Ledingham
Received: 3 November 2014 / Accepted: 16 December 2014 / Published: 29 December 2014
(This article belongs to the Special Issue Casting Light on Cancer Therapy)
View Full-Text   |   Download PDF [3168 KB, uploaded 29 December 2014]   |  

Abstract

We present a new external-beam radiation therapy system using very-high-energy (VHE) electron/photon beams generated by a centimeter-scale laser plasma accelerator built in a robotic system. Most types of external-beam radiation therapy are delivered using a machine called a medical linear accelerator driven by radio frequency (RF) power amplifiers, producing electron beams with an energy range of 6–20 MeV, in conjunction with modern radiation therapy technologies for effective shaping of three-dimensional dose distributions and spatially accurate dose delivery with imaging verification. However, the limited penetration depth and low quality of the transverse penumbra at such electron beams delivered from the present RF linear accelerators prevent the implementation of advanced modalities in current cancer treatments. These drawbacks can be overcome if the electron energy is increased to above 50 MeV. To overcome the disadvantages of the present RF-based medical accelerators, harnessing recent advancement of laser-driven plasma accelerators capable of producing 1-GeV electron beams in a 1-cm gas cell, we propose a new embodiment of the external-beam radiation therapy robotic system delivering very high-energy electron/photon beams with an energy of 50–250 MeV; it is more compact, less expensive, and has a simpler operation and higher performance in comparison with the current radiation therapy system. View Full-Text
Keywords: external-beam radiation therapy; very-high-energy electron beam cancer therapy; laser plasma accelerators; robotic system external-beam radiation therapy; very-high-energy electron beam cancer therapy; laser plasma accelerators; robotic system
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nakajima, K.; Yuan, J.; Chen, L.; Sheng, Z. Laser-Driven Very High Energy Electron/Photon Beam Radiation Therapy in Conjunction with a Robotic System. Appl. Sci. 2015, 5, 1-20.

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