Appl. Sci. 2013, 3(3), 614-623; doi:10.3390/app3030614
Communication

Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles

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Received: 13 May 2013; in revised form: 26 June 2013 / Accepted: 5 July 2013 / Published: 24 July 2013
(This article belongs to the Special Issue Greener and Sustainable Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis. Here we describe water-based MW-assisted solid-phase synthesis using Boc-amino acid nanoparticles. The microwave irradiation allowed rapid solid-phase reaction of nanoparticle reactants on the resin in water. We also demonstrated the syntheses of Leu-enkephalin, Tyr-Gly-Gly-Phe-Leu-OH, and difficult sequence model peptide, Val-Ala-Val-Ala-Gly-OH, using our water-based MW-assisted protocol with Boc-amino acid nanoparticles.
Keywords: aqueous synthesis; solid-phase peptide synthesis; microwave assisted synthesis; nanoparticles; Boc chemistry
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MDPI and ACS Style

Hojo, K.; Shinozaki, N.; Nozawa, Y.; Fukumori, Y.; Ichikawa, H. Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles. Appl. Sci. 2013, 3, 614-623.

AMA Style

Hojo K, Shinozaki N, Nozawa Y, Fukumori Y, Ichikawa H. Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles. Applied Sciences. 2013; 3(3):614-623.

Chicago/Turabian Style

Hojo, Keiko; Shinozaki, Natsuki; Nozawa, Yoshimi; Fukumori, Yoshinobu; Ichikawa, Hideki. 2013. "Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles." Appl. Sci. 3, no. 3: 614-623.

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