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Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles
Faculty of Pharmaceutical Sciences & Cooperative Research Center of Life Sciences, Kobe Gakuin University, Chuo-ku, Kobe 650-8586, Japan
* Author to whom correspondence should be addressed.
Received: 13 May 2013; in revised form: 26 June 2013 / Accepted: 5 July 2013 / Published: 24 July 2013
Abstract: We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis. Here we describe water-based MW-assisted solid-phase synthesis using Boc-amino acid nanoparticles. The microwave irradiation allowed rapid solid-phase reaction of nanoparticle reactants on the resin in water. We also demonstrated the syntheses of Leu-enkephalin, Tyr-Gly-Gly-Phe-Leu-OH, and difficult sequence model peptide, Val-Ala-Val-Ala-Gly-OH, using our water-based MW-assisted protocol with Boc-amino acid nanoparticles.
Keywords: aqueous synthesis; solid-phase peptide synthesis; microwave assisted synthesis; nanoparticles; Boc chemistry
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Hojo, K.; Shinozaki, N.; Nozawa, Y.; Fukumori, Y.; Ichikawa, H. Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles. Appl. Sci. 2013, 3, 614-623.
Hojo K, Shinozaki N, Nozawa Y, Fukumori Y, Ichikawa H. Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles. Applied Sciences. 2013; 3(3):614-623.
Hojo, Keiko; Shinozaki, Natsuki; Nozawa, Yoshimi; Fukumori, Yoshinobu; Ichikawa, Hideki. 2013. "Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles." Appl. Sci. 3, no. 3: 614-623.