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Appl. Sci. 2012, 2(1), 1-12; doi:10.3390/app2010001
Communication

Chiral β-Amino Alcohols as Ligands for the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of N-Phosphinyl Ketimines

, *  and *
Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain
* Authors to whom correspondence should be addressed.
Received: 1 November 2011 / Revised: 22 December 2011 / Accepted: 28 December 2011 / Published: 9 January 2012
(This article belongs to the Special Issue Feature Papers)
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Abstract

Some chiral β-amino alcohols have been evaluated as potential ligands for the ruthenium-catalyzed asymmetric transfer hydrogenation (ATH) of N-phosphinyl ketimines in isopropyl alcohol. The ruthenium complex prepared from [RuCl2(p-cymene)]2 and (1S,2R)-1-amino-2-indanol has shown to be an efficient catalyst for the ATH of several N-(diphenylphosphinyl)imines, affording the reduction products in very good isolated yields and enantiomeric excesses up to 82%. The inherent rigidity of the indane ring system present in the ligand seems to be very important to achieve good enantioselectivities.
Keywords: N-(diphenylphosphinyl)imine; asymmetric transfer hydrogenation; ruthenium catalyst; β-amino alcohol; isopropyl alcohol N-(diphenylphosphinyl)imine; asymmetric transfer hydrogenation; ruthenium catalyst; β-amino alcohol; isopropyl alcohol
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pablo, Ó.; Guijarro, D.; Yus, M. Chiral β-Amino Alcohols as Ligands for the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of N-Phosphinyl Ketimines. Appl. Sci. 2012, 2, 1-12.

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