Appl. Sci. 2012, 2(1), 1-12; doi:10.3390/app2010001
Communication

Chiral β-Amino Alcohols as Ligands for the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of N-Phosphinyl Ketimines

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Received: 1 November 2011; in revised form: 22 December 2011 / Accepted: 28 December 2011 / Published: 9 January 2012
(This article belongs to the Special Issue Feature Papers)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Some chiral β-amino alcohols have been evaluated as potential ligands for the ruthenium-catalyzed asymmetric transfer hydrogenation (ATH) of N-phosphinyl ketimines in isopropyl alcohol. The ruthenium complex prepared from [RuCl2(p-cymene)]2 and (1S,2R)-1-amino-2-indanol has shown to be an efficient catalyst for the ATH of several N-(diphenylphosphinyl)imines, affording the reduction products in very good isolated yields and enantiomeric excesses up to 82%. The inherent rigidity of the indane ring system present in the ligand seems to be very important to achieve good enantioselectivities.
Keywords: N-(diphenylphosphinyl)imine; asymmetric transfer hydrogenation; ruthenium catalyst; β-amino alcohol; isopropyl alcohol
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MDPI and ACS Style

Pablo, Ó.; Guijarro, D.; Yus, M. Chiral β-Amino Alcohols as Ligands for the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of N-Phosphinyl Ketimines. Appl. Sci. 2012, 2, 1-12.

AMA Style

Pablo Ó, Guijarro D, Yus M. Chiral β-Amino Alcohols as Ligands for the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of N-Phosphinyl Ketimines. Applied Sciences. 2012; 2(1):1-12.

Chicago/Turabian Style

Pablo, Óscar; Guijarro, David; Yus, Miguel. 2012. "Chiral β-Amino Alcohols as Ligands for the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of N-Phosphinyl Ketimines." Appl. Sci. 2, no. 1: 1-12.

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