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Med. Sci. 2016, 4(4), 19; doi:10.3390/medsci4040019

Do Sex Differences in Respiratory Burst Enzyme Activities Exist in Human Immunodeficiency Virus-1 Infection?

Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin 300001, Nigeria
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Author to whom correspondence should be addressed.
Academic Editor: Ignacio Martin-Loeches
Received: 5 September 2016 / Revised: 7 November 2016 / Accepted: 9 November 2016 / Published: 15 November 2016
(This article belongs to the Section Immunology and Infectious Diseases)
View Full-Text   |   Download PDF [207 KB, uploaded 16 November 2016]

Abstract

Studies have shown that human immunodeficiency virus type 1 (HIV-1) disproportionally affects more females than males. Affected individuals are susceptible to infections due to depressed immunity, qualitative defects in phagocytic function and altered phagocytosis as well as lowered oxidative burst capacity. This study seeks to determine whether sex differences exist in serum activities of respiratory burst enzymes in HIV-1–infected female and male subjects. Serum myeloperoxidase, catalase and superoxide dismutase activities were assayed in 170 confirmed HIV-1 positive and 50 HIV-1 negative subjects using ELISA. Data were analyzed using Student’s t-test and p values of less than 0.05 were considered significant. The measured enzyme activities were significantly higher (p < 0.001) in females than males in HIV-1 negative subjects while no sex differences were observed in HIV-1 positive subjects. The absence of sex differences in the activities of respiratory burst enzymes in HIV-1 infection may be due to immune activation as a result of active phagocytic leukocytes, immune reactivity and inflammation. View Full-Text
Keywords: human immunodeficiency virus type 1; respiratory burst enzymes; sex differences human immunodeficiency virus type 1; respiratory burst enzymes; sex differences
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Emokpae, M.A.; Mrakpor, B.A. Do Sex Differences in Respiratory Burst Enzyme Activities Exist in Human Immunodeficiency Virus-1 Infection? Med. Sci. 2016, 4, 19.

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