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Med. Sci. 2016, 4(4), 17; doi:10.3390/medsci4040017

An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases

1
Centre for Excellence for mountain Biology, Uttarakhand Council for Biotechnology, Haldi 263146, India
2
Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
3
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
4
Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
*
Author to whom correspondence should be addressed.
Academic Editor: Hung-Yun Lin
Received: 9 August 2016 / Revised: 13 October 2016 / Accepted: 18 October 2016 / Published: 27 October 2016
(This article belongs to the Section Cancer and Cancer-Related Research)
View Full-Text   |   Download PDF [224 KB, uploaded 27 October 2016]

Abstract

The present study was aimed to evaluate the levels of oxidative stress markers in breast diseases by measuring the 8-hydroxy-2-deoxyguanosine (8-OHdG), vitamin A, vitamin C, vitamin E, and total antioxidant status (TAS) alterations in relation to cell proliferation activity and disease progression. Significant increases in the level of the oxidative damage marker 8-OHdG and cell proliferation activity were observed in breast carcinoma patients in comparison to benign and normal controls, which were accompanied by a significant decrease in non-enzymatic antioxidants and TAS concentrations (p < 0.05). 8-OHdG and cell proliferation levels were negatively correlated with non-enzymatic antioxidants, namely, vitamin A, vitamin C, and vitamin E levels and total antioxidant activity. Altered levels of biomarkers of oxidative stress and cell proliferation activity among the malignant, the benign, and the controls suggest a correlation of increased oxidative stress and cell proliferation activity in the progression of disease in breast carcinoma patients. In conclusion, our results showed that the characterized biomarkers (i.e., low levels of vitamin A, C and D, and the TAS status; and high levels of 8-OHdG) could be used as a suitable method for detecting subjects with malignant and benign breast diseases. View Full-Text
Keywords: 8-hydroxy-2-deoxyguanosine; vitamin A; vitamin C; vitamin E; reactive oxygen species; total antioxidant status 8-hydroxy-2-deoxyguanosine; vitamin A; vitamin C; vitamin E; reactive oxygen species; total antioxidant status
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Karki, K.; Pande, D.; Negi, R.; Khanna, R.S.; Khanna, H. An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases. Med. Sci. 2016, 4, 17.

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