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Med. Sci. 2016, 4(3), 15; doi:10.3390/medsci4030015

Androgen Receptor Expression in Thai Breast Cancer Patients

1
Division of Environmental Toxicology, Chulabhorn Graduate Institute, Bangkok 10210, Thailand
2
Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Bangkok 10210, Thailand
3
Center of Excellence on Environmental Health, Toxicology and Management of Chemicals, Bangkok 10400, Thailand
4
Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nontaburi 11000, Thailand
5
Institute for Risk Assessment Sciences, Utrecht University, Utrecht NL-3508, The Netherlands
6
Department of Surgery, Charoenkrung Pracharuk Hospital, Bangkok 10120, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Hung-Yun Lin
Received: 5 July 2016 / Revised: 19 August 2016 / Accepted: 2 September 2016 / Published: 14 September 2016
(This article belongs to the Section Cancer and Cancer-Related Research)
View Full-Text   |   Download PDF [1680 KB, uploaded 14 September 2016]   |  

Abstract

The aim of this study was to investigate prevalence and related factors of androgen receptor (AR) expression in Thai breast cancer patients. A descriptive study was done in 95 patients, who were admitted to Charoenkrung Pracharak Hospital, Bangkok (2011–2013). Statistical relationships were examined between AR protein expression, tumor status, and patient characteristics. Compared with those from Western countries, ethnic Thai patients were younger at age of diagnosis and had a higher proliferative index (high Ki-67 expression), which indicates unfavorable prognosis. In addition, 91% of the Thai breast tumors that were positive for any of the following receptors, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) also expressed the AR protein, while in triple negative breast tumors only 33% were AR positive. ER and PR expression was positively related with AR expression, while AR expression was inversely correlated to Ki-67 expression. AR status was strongly correlated with ER and PR status in Thai patients. There is an inverse relationship between Ki-67 and AR, which suggests that AR may be a prognostic factor for breast cancer. View Full-Text
Keywords: breast cancer; androgens; androgen receptors breast cancer; androgens; androgen receptors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chottanapund, S.; Van Duursen, M.B.M.; Ratchaworapong, K.; Navasumrit, P.; Ruchirawat, M.; Van den Berg, M. Androgen Receptor Expression in Thai Breast Cancer Patients. Med. Sci. 2016, 4, 15.

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