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Actuators 2015, 4(4), 267-280; doi:10.3390/act4040267

Role of α and β Transmembrane Domains in Integrin Clustering

1
Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran
2
Department of Electrical Engineering, York University, Toronto, M3J1P3, Canada
*
Authors to whom correspondence should be addressed.
Academic Editor: Delbert Tesar
Received: 1 October 2015 / Accepted: 11 November 2015 / Published: 20 November 2015
(This article belongs to the Special Issue Biophysical Micro- and Nano-Actuators)
View Full-Text   |   Download PDF [1110 KB, uploaded 20 November 2015]   |  

Abstract

Integrins are transmembrane proteins playing a crucial role in the mechanical signal transduction from the outside to the inside of a cell, and vice versa. Nevertheless, this signal transduction could not be implemented by a single protein. Rather, in order for integrins to be able to participate in signal transduction, they need to be activated and produce clusters first. As integrins consist of α- and β-subunits that are separate in the active state, studying both subunits separately is of a great importance, for, in the active state, the distance between α- and β-subunits is long enough that they do not influence one another significantly. Thus, this study aims to investigate the tendency of transmembrane domains of integrins to form homodimers. We used both Steered and MARTINI Coarse-grained molecular dynamics method to perform our simulations, mainly because of a better resolution and computational feasibility that each of these methods could provide to us. Using the Steered molecular dynamics method for α- and β-subunits, we found that the localized lipid packing prevented them from clustering. Nonetheless, the lipid packing phenomenon was found to be an artifact after investigating this process using a coarse grained (CG) model. Exploiting the coarse-grained molecular dynamics simulations, we found that α- and β-subunits tend to form a stable homo-dimer. View Full-Text
Keywords: integrin; molecular dynamics; oligomerization integrin; molecular dynamics; oligomerization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shamloo, A.; Golgoon, A.; Zadeh, E.G. Role of α and β Transmembrane Domains in Integrin Clustering. Actuators 2015, 4, 267-280.

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