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Pathogens 2018, 7(1), 6; doi:10.3390/pathogens7010006

What Could Be the Role of Antifungal Lock-Solutions? From Bench to Bedside

Laboratory of Ecology and Biology of Interactions, University of Poitiers, UMR CNRS 7267, F-86073 Poitiers, France
Faculty of Medicine and Pharmacy, University of Poitiers, F-86073 Poitiers, France
CHU Poitiers, Infectious and Tropical Disease Unit, F-86073 Poitiers, France
INSERM U1070, F-86073 Poitiers, France
Author to whom correspondence should be addressed.
Received: 28 November 2017 / Revised: 2 January 2018 / Accepted: 3 January 2018 / Published: 6 January 2018
(This article belongs to the Special Issue Pathogenesis and Virulence of Candida albicans and Candida glabrata)
View Full-Text   |   Download PDF [239 KB, uploaded 6 January 2018]


Candidemia related to the presence of a biofilm are often reported in patients with vascular catheters. Once they are mature, biofilms are persistent infectious reservoirs, and the yeasts dispersed from biofilms can cause infections. Sessile yeasts typically display increased levels of resistance to most antimicrobial agents and systemic treatments usually fail to eradicate previously formed fungal biofilms. In a curative strategy, antifungal lock therapy may help to sterilize catheters, with very high concentrations of antifungal agents, which are not compatible with systemic use. This strategy has been studied by several authors in in vitro and in vivo studies, and more rarely, in clinical settings for adult and paediatric patients. Our study aims to assess the efficacy of the antifungal solutions used for lock therapy and demonstrated by the different teams. View Full-Text
Keywords: biofilm; antifungal agents; candidemia; catheter carrier patient biofilm; antifungal agents; candidemia; catheter carrier patient
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Imbert, C.; Rammaert, B. What Could Be the Role of Antifungal Lock-Solutions? From Bench to Bedside. Pathogens 2018, 7, 6.

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