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Pathogens 2018, 7(1), 11; https://doi.org/10.3390/pathogens7010011

Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans

Section of Immunology, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 266a, CH-8057 Zürich, Switzerland
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Received: 22 December 2017 / Revised: 11 January 2018 / Accepted: 12 January 2018 / Published: 17 January 2018
(This article belongs to the Special Issue Pathogenesis and Virulence of Candida albicans and Candida glabrata)
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Abstract

The incidence of human infections caused by the opportunistic fungal pathogen Candida albicans is on the rise due to increasing numbers of immunosuppressed patients. The importance of the immune system in preventing overgrowth of the colonizing fungus and thereby limiting infection is well recognized and host protective mechanisms widely investigated. Only recently, it was recognized that the natural diversity in the fungal species could also influence the outcome of the interaction between the fungus and the host. C. albicans strain-specific differences are complex and their regulation at the genomic, genetic, and epigenetic level and by environmental factors is only partially understood. In this review, we provide an overview of the natural diversity of C. albicans and discuss how it impacts host-fungal interactions and thereby affects the balance between commensalism versus disease. View Full-Text
Keywords: Candida albicans; intraspecies diversity; genomic and genetic variations; morphotypes; phenotypes; host-pathogen interaction Candida albicans; intraspecies diversity; genomic and genetic variations; morphotypes; phenotypes; host-pathogen interaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Braunsdorf, C.; LeibundGut-Landmann, S. Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans. Pathogens 2018, 7, 11.

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