Next Article in Journal
The Listeria monocytogenes Key Virulence Determinants hly and prfA are involved in Biofilm Formation and Aggregation but not Colonization of Fresh Produce
Next Article in Special Issue
Pathogenesis and Animal Models of Post-Primary (Bronchogenic) Tuberculosis, A Review
Previous Article in Journal
On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts
Article Menu

Export Article

Open AccessReview
Pathogens 2018, 7(1), 17; https://doi.org/10.3390/pathogens7010017

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Department of Pharmaceutical Sciences, Università del Piemonte Orientale “A. Avogadro”, Largo Donegani 2, 28100 Novara, Italy
*
Author to whom correspondence should be addressed.
Received: 27 December 2017 / Revised: 26 January 2018 / Accepted: 28 January 2018 / Published: 1 February 2018
(This article belongs to the Special Issue Mechanisms of Mycobacterium tuberculosis Pathogenesis)
View Full-Text   |   Download PDF [787 KB, uploaded 1 February 2018]   |  

Abstract

Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure of tuberculosis involves prolonged therapies which complicate the compliance and monitoring of drug administration and treatment. Moreover, the only available antitubercular vaccine fails to provide an effective shield against adult lung tuberculosis, which is the most prevalent form. Hence, there is a pressing need for effective antitubercular drugs and vaccines. This review highlights recent advances in the study of selected M. tuberculosis key molecular determinants of infection and vulnerable targets whose structures could be exploited for the development of new antitubercular agents. View Full-Text
Keywords: Mycobacterium tuberculosis; tuberculosis; antitubercular drugs; target identification; drug discovery Mycobacterium tuberculosis; tuberculosis; antitubercular drugs; target identification; drug discovery
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ferraris, D.M.; Miggiano, R.; Rossi, F.; Rizzi, M. Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets. Pathogens 2018, 7, 17.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top