On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts
School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
Author to whom correspondence should be addressed.
Received: 10 January 2018 / Revised: 23 January 2018 / Accepted: 25 January 2018 / Published: 28 January 2018
Human cytomegalovirus (HCMV) is a member of the
-herpesvirus subfamily within Herpesviridae that is nearly ubiquitous in human populations, and infection generally results only in mild symptoms. However, symptoms can be severe in immunonaive individuals, and transplacental congenital infection of HCMV can result in serious neurological sequelae. Recent work has revealed much about the demographic and selective forces shaping the evolution of congenitally transmitted HCMV both on the level of hosts and within host compartments, providing insight into the dynamics of congenital infection, reinfection, and evolution of HCMV with important implications for the development of effective treatments and vaccines.
This is an open access article distributed under the Creative Commons Attribution License
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style
Sackman, A.M.; Pfeifer, S.P.; Kowalik, T.F.; Jensen, J.D. On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts. Pathogens 2018, 7, 16.
Sackman AM, Pfeifer SP, Kowalik TF, Jensen JD. On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts. Pathogens. 2018; 7(1):16.
Sackman, Andrew M.; Pfeifer, Susanne P.; Kowalik, Timothy F.; Jensen, Jeffrey D. 2018. "On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts." Pathogens 7, no. 1: 16.
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