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Pathogens 2016, 5(3), 47; doi:10.3390/pathogens5030047

Recruitment of Factor H to the Streptococcus suis Cell Surface is Multifactorial

1
Research Group on Infectious Diseases in Production Animals and Swine and Poultry Infectious Diseases Research Centre, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, J2S 7C6, Quebec, Canada
2
Oral Ecology Research Group, Faculty of Dentistry, Laval University, Quebec City, J2S 7C6, Quebec, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Lawrence S. Young
Received: 16 May 2016 / Revised: 22 June 2016 / Accepted: 4 July 2016 / Published: 7 July 2016
(This article belongs to the Special Issue Streptococcus suis)
View Full-Text   |   Download PDF [4480 KB, uploaded 7 July 2016]   |  

Abstract

Streptococcus suis is an important bacterial swine pathogen and a zoonotic agent. Recently, two surface proteins of S. suis, Fhb and Fhbp, have been described for their capacity to bind factor H—a soluble complement regulatory protein that protects host cells from complement-mediated damages. Results obtained in this study showed an important role of host factor H in the adhesion of S. suis to epithelial and endothelial cells. Both Fhb and Fhbp play, to a certain extent, a role in such increased factor H-dependent adhesion. The capsular polysaccharide (CPS) of S. suis, independently of the presence of its sialic acid moiety, was also shown to be involved in the recruitment of factor H. However, a triple mutant lacking Fhb, Fhbp and CPS was still able to recruit factor H resulting in the degradation of C3b in the presence of factor I. In the presence of complement factors, the double mutant lacking Fhb and Fhbp was similarly phagocytosed by human macrophages and killed by pig blood when compared to the wild-type strain. In conclusion, this study suggests that recruitment of factor H to the S. suis cell surface is multifactorial and redundant. View Full-Text
Keywords: Streptococcus suis; factor H; factor H-binding proteins; adhesion; polysaccharide capsule; phagocytosis; C3b; complement Streptococcus suis; factor H; factor H-binding proteins; adhesion; polysaccharide capsule; phagocytosis; C3b; complement
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MDPI and ACS Style

Roy, D.; Grenier, D.; Segura, M.; Mathieu-Denoncourt, A.; Gottschalk, M. Recruitment of Factor H to the Streptococcus suis Cell Surface is Multifactorial. Pathogens 2016, 5, 47.

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