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Pathogens 2013, 2(3), 436-445; doi:10.3390/pathogens2030436
Review

The Functional Role of Prion Protein (PrPC) on Autophagy

1
,
1
 and
1,2,*
1 Ilsong Institute of Life Science, Hallym University, 1605-4 Gwanyang-dong, Dongan-gu, Anyang, Gyeonggi-do 431-060, Republic of Korea 2 Department of Microbiology, College of Medicine, Hallym University, 1 Okcheon-dong, Chuncheon, Kangwon-do 200-702, Republic of Korea
* Author to whom correspondence should be addressed.
Received: 2 May 2013 / Revised: 11 June 2013 / Accepted: 18 June 2013 / Published: 26 June 2013
(This article belongs to the Special Issue Prions)
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Abstract

Cellular prion protein (PrPC) plays an important role in the cellular defense against oxidative stress. However, the exact protective mechanism of PrPC is unclear. Autophagy is essential for survival, differentiation, development, and homeostasis in several organisms. Although the role that autophagy plays in neurodegenerative disease has yet to be established, it is clear that autophagy-induced cell death is observed in neurodegenerative disorders that exhibit protein aggregations. Moreover, autophagy can promote cell survival and cell death under various conditions. In this review, we describe the involvement of autophagy in prion disease and the effects of PrPC.
Keywords: prion; Prnp-deficient; prion diseases; autophagy; autophagic flux; oxidative stress prion; Prnp-deficient; prion diseases; autophagy; autophagic flux; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shin, H.-Y.; Oh, J.-M.; Kim, Y.-S. The Functional Role of Prion Protein (PrPC) on Autophagy. Pathogens 2013, 2, 436-445.

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