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Pathogens 2013, 2(2), 288-356; doi:10.3390/pathogens2020288
Review

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

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Received: 19 April 2013; in revised form: 1 May 2013 / Accepted: 8 May 2013 / Published: 13 May 2013
(This article belongs to the Special Issue Pathogen Infection Models)
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Abstract: The influence of microorganisms growing as sessile communities in a large number of human infections has been extensively studied and recognized for 30–40 years, therefore warranting intense scientific and medical research. Nonetheless, mimicking the biofilm-life style of bacteria and biofilm-related infections has been an arduous task. Models used to study biofilms range from simple in vitro to complex in vivo models of tissues or device-related infections. These different models have progressively contributed to the current knowledge of biofilm physiology within the host context. While far from a complete understanding of the multiple elements controlling the dynamic interactions between the host and biofilms, we are nowadays witnessing the emergence of promising preventive or curative strategies to fight biofilm-related infections. This review undertakes a comprehensive analysis of the literature from a historic perspective commenting on the contribution of the different models and discussing future venues and new approaches that can be merged with more traditional techniques in order to model biofilm-infections and efficiently fight them.
Keywords: biofilm, in vitro models; surrogate non-mammalian models; tissue-associated biofilm models; device-related biofilm models biofilm, in vitro models; surrogate non-mammalian models; tissue-associated biofilm models; device-related biofilm models
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lebeaux, D.; Chauhan, A.; Rendueles, O.; Beloin, C. From in vitro to in vivo Models of Bacterial Biofilm-Related Infections. Pathogens 2013, 2, 288-356.

AMA Style

Lebeaux D, Chauhan A, Rendueles O, Beloin C. From in vitro to in vivo Models of Bacterial Biofilm-Related Infections. Pathogens. 2013; 2(2):288-356.

Chicago/Turabian Style

Lebeaux, David; Chauhan, Ashwini; Rendueles, Olaya; Beloin, Christophe. 2013. "From in vitro to in vivo Models of Bacterial Biofilm-Related Infections." Pathogens 2, no. 2: 288-356.

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