Pathogens 2013, 2(1), 33-54; doi:10.3390/pathogens2010033
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Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance

1 Department of Laboratory Medicine & Pathobiology, University of Toronto, Canada 2 Department of Pathology & Laboratory Medicine, The University of Calgary, Calgary, AB, Canada 3 Department of Microbiology, Immunology, and Infectious Diseases, The University of Calgary, Diagnostic & Scientific Centre, Room 1W-416, 9-3535 Research Road NW, Calgary, AB T2L 2K8, Canada
* Author to whom correspondence should be addressed.
Received: 8 December 2012; in revised form: 18 January 2013 / Accepted: 23 January 2013 / Published: 4 February 2013
(This article belongs to the Special Issue Host-Parasite Interactions)
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Abstract: Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports the role for Hsp90 inhibitors as adjunctive drugs able to restore susceptibility to traditionally efficacious compounds like chloroquine.
Keywords: malaria; hsp90; antimalarial resistance

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MDPI and ACS Style

Shahinas, D.; Folefoc, A.; Pillai, D.R. Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance. Pathogens 2013, 2, 33-54.

AMA Style

Shahinas D, Folefoc A, Pillai DR. Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance. Pathogens. 2013; 2(1):33-54.

Chicago/Turabian Style

Shahinas, Dea; Folefoc, Asongna; Pillai, Dylan R. 2013. "Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance." Pathogens 2, no. 1: 33-54.

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