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Pathogens 2013, 2(1), 33-54; doi:10.3390/pathogens2010033
Review

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance

1
,
2,3
 and
2,3,*
1 Department of Laboratory Medicine & Pathobiology, University of Toronto, Canada 2 Department of Pathology & Laboratory Medicine, The University of Calgary, Calgary, AB, Canada 3 Department of Microbiology, Immunology, and Infectious Diseases, The University of Calgary, Diagnostic & Scientific Centre, Room 1W-416, 9-3535 Research Road NW, Calgary, AB T2L 2K8, Canada
* Author to whom correspondence should be addressed.
Received: 8 December 2012 / Revised: 18 January 2013 / Accepted: 23 January 2013 / Published: 4 February 2013
(This article belongs to the Special Issue Host-Parasite Interactions)
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Abstract

Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports the role for Hsp90 inhibitors as adjunctive drugs able to restore susceptibility to traditionally efficacious compounds like chloroquine.
Keywords: malaria; hsp90; antimalarial resistance malaria; hsp90; antimalarial resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shahinas, D.; Folefoc, A.; Pillai, D.R. Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance. Pathogens 2013, 2, 33-54.

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