Next Article in Journal / Special Issue
Goblet Cells and Mucins: Role in Innate Defense in Enteric Infections
Previous Article in Journal
Defensin Production by Human Limbo-Corneal Fibroblasts Infected with Mycobacteria
Pathogens 2013, 2(1), 33-54; doi:10.3390/pathogens2010033
Review

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance

1
,
2,3
 and
2,3,*
1 Department of Laboratory Medicine & Pathobiology, University of Toronto, Canada 2 Department of Pathology & Laboratory Medicine, The University of Calgary, Calgary, AB, Canada 3 Department of Microbiology, Immunology, and Infectious Diseases, The University of Calgary, Diagnostic & Scientific Centre, Room 1W-416, 9-3535 Research Road NW, Calgary, AB T2L 2K8, Canada
* Author to whom correspondence should be addressed.
Received: 8 December 2012 / Revised: 18 January 2013 / Accepted: 23 January 2013 / Published: 4 February 2013
(This article belongs to the Special Issue Host-Parasite Interactions)
View Full-Text   |   Download PDF [623 KB, uploaded 4 February 2013]   |   Browse Figures

Abstract

Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports the role for Hsp90 inhibitors as adjunctive drugs able to restore susceptibility to traditionally efficacious compounds like chloroquine.
Keywords: malaria; hsp90; antimalarial resistance malaria; hsp90; antimalarial resistance
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Shahinas, D.; Folefoc, A.; Pillai, D.R. Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance. Pathogens 2013, 2, 33-54.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert