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Epigenomes 2018, 2(1), 3; doi:10.3390/epigenomes2010003

5-Hydroxymethylcytosine (5hmC), or How to Identify Your Favorite Cell

1
Institute of Biology Valrose (iBV), The National Center for Scientific Research (CNRS)—National Institute of Health and Medical Research (Inserm), Université Côte d’Azur, 06108 Nice, France
2
Laboratory 305-Sur, Department of Cellular Biology and Development, Institute of Cellular Physiology, National Autonomous University of Mexico (UNAM), Coyoacán, 04510 Ciudad de México, Mexico
3
Cancer Research Centre of Lyon (CRCL), Inserm U 1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, 28 rue Laennec, 69373 Lyon CEDEX 08, France
*
Author to whom correspondence should be addressed.
Received: 20 December 2017 / Revised: 23 January 2018 / Accepted: 23 January 2018 / Published: 30 January 2018
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Abstract

Recently described as the sixth base of the DNA macromolecule, the precise role of 5-hydroxymethylcytosine (5hmC) is the subject of debate. Early studies indicate that it is functionally distinct from cytosine DNA methylation (5mC), and there is evidence for 5hmC being a stable derivate of 5mC, rather than just an intermediate of demethylation. Moreover, 5hmC events correlate in time and space with key differentiation steps in mammalian cells. Such events span the three embryonic germ layers and multiple progenitor cell subtypes, suggesting a general mechanism. Because of the growing understanding of the role of progenitor cells in disease origin, we attempted to provide a detailed summary on the currently available literature supporting 5hmC as a key player in adult progenitor cell differentiation. This summary consolidates the emerging role for 5hmC in defining cellular fate. View Full-Text
Keywords: DNA methylation; progenitor cells; differentiation; 5mC; 5hmC DNA methylation; progenitor cells; differentiation; 5mC; 5hmC
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Ecsedi, S.; Rodríguez-Aguilera, J.R.; Hernandez-Vargas, H. 5-Hydroxymethylcytosine (5hmC), or How to Identify Your Favorite Cell. Epigenomes 2018, 2, 3.

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