Table of Contents
Epigenomes, Volume 2, Issue 1 (March 2018)
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Cover Story (view full-size image) While most cells of the same organism contain an identical DNA sequence, what governs the diversity [...] Read more. While most cells of the same organism contain an identical DNA sequence, what governs the diversity of cell phenotypes is a matter of intense research. A novel epigenetic mark, 5-hydroxymethylcytosine (5hmC), originally described as an intermediate during active DNA-demethylation, is emerging as a stable modified base with unique functions. In this review, we summarize recent evidence suggesting that dynamic distribution of 5hmC could be an acquired "fingerprint" of cell identity during adult progenitor cell differentiation. View this paper