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Epigenomes 2018, 2(1), 1; https://doi.org/10.3390/epigenomes2010001

Drosophila DNA-Binding Proteins in Polycomb Repression

Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia
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Received: 5 November 2017 / Revised: 10 January 2018 / Accepted: 10 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue Polycomb and Trithorax Group of Proteins in Development and Disease)
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Abstract

The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms. Polycomb group (PcG) proteins are key epigenetic regulators responsible for gene repression, and dysregulation of their activities leads to developmental abnormalities and diseases. PcG proteins were first identified in Drosophila, which still remains the most convenient system for studying PcG-dependent repression. In the Drosophila genome, these proteins bind to DNA regions called Polycomb response elements (PREs). A major role in the recruitment of PcG proteins to PREs is played by DNA-binding factors, several of which have been characterized in detail. However, current knowledge is insufficient for comprehensively describing the mechanism of this process. In this review, we summarize and discuss the available data on the role of DNA-binding proteins in PcG recruitment to chromatin. View Full-Text
Keywords: DNA binding; Polycomb; Polycomb response elements; PRE; recruitment; epigenetics; chromatin; transcription regulation; repression; silencing DNA binding; Polycomb; Polycomb response elements; PRE; recruitment; epigenetics; chromatin; transcription regulation; repression; silencing
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Erokhin, M.; Georgiev, P.; Chetverina, D. Drosophila DNA-Binding Proteins in Polycomb Repression. Epigenomes 2018, 2, 1.

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