Drosophila DNA-Binding Proteins in Polycomb Repression
AbstractThe formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms. Polycomb group (PcG) proteins are key epigenetic regulators responsible for gene repression, and dysregulation of their activities leads to developmental abnormalities and diseases. PcG proteins were first identified in Drosophila, which still remains the most convenient system for studying PcG-dependent repression. In the Drosophila genome, these proteins bind to DNA regions called Polycomb response elements (PREs). A major role in the recruitment of PcG proteins to PREs is played by DNA-binding factors, several of which have been characterized in detail. However, current knowledge is insufficient for comprehensively describing the mechanism of this process. In this review, we summarize and discuss the available data on the role of DNA-binding proteins in PcG recruitment to chromatin. View Full-Text
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Erokhin, M.; Georgiev, P.; Chetverina, D. Drosophila DNA-Binding Proteins in Polycomb Repression. Epigenomes 2018, 2, 1.
Erokhin M, Georgiev P, Chetverina D. Drosophila DNA-Binding Proteins in Polycomb Repression. Epigenomes. 2018; 2(1):1.Chicago/Turabian Style
Erokhin, Maksim; Georgiev, Pavel; Chetverina, Darya. 2018. "Drosophila DNA-Binding Proteins in Polycomb Repression." Epigenomes 2, no. 1: 1.
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