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Epigenomes 2017, 1(1), 3; doi:10.3390/epigenomes1010003

New Frontiers in Melanoma Epigenetics—The More We Know, the More We Don’t Know

1
XXXIII Nicolaus Copernicus Bilingual High School in Warsaw, Józefa Bema street 76, 01-225 Warsaw, Poland
2
School of Clinical Medicine, University of Cambridge, The Old Schools, Trinity Ln, Cambridge CB2 1TN, UK
3
Tel Aviv University, Sheba Medical Center Hospital, Cancer Research Centre, Tel Hashomer, 52621 Ramat Gan, Israel
*
Author to whom correspondence should be addressed.
Received: 31 December 2016 / Accepted: 25 January 2017 / Published: 30 January 2017
(This article belongs to the Special Issue Biological Methylation in Development and Cancer)
View Full-Text   |   Download PDF [287 KB, uploaded 10 February 2017]

Abstract

Skin cancer is one of the most common neoplasms worldwide, with a surprising tendency to increase its incidence. As with many cancer types nowadays, early diagnosis and proper management carries an excellent prognosis, up to 5-year survival rate of above 95% for most skin cancers, even though the long-term survival rate among metastatic melanoma patients remains only 5%. This review aims to summarize recent discoveries in epigenetic changes connected with cutaneous malignant melanoma (CMM), comprising of DNA methylation, histone modifications, miRNA regulation, nucleosome positioning and chromatin remodelling. Undoubtedly, personalised medicine based on both genetic and epigenetic changes of cancer is the future, the question remains: how long will it take to transport this treatment from the bench to the bedside? View Full-Text
Keywords: Epigenetics; melanoma; miRNA; epigenetic changes in melanoma; skin cancer Epigenetics; melanoma; miRNA; epigenetic changes in melanoma; skin cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nguyen, M.; Dobosz, P. New Frontiers in Melanoma Epigenetics—The More We Know, the More We Don’t Know. Epigenomes 2017, 1, 3.

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