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Epigenomes 2017, 1(1), 4; doi:10.3390/epigenomes1010004

Lysine-Specific Histone Demethylases Contribute to Cellular Differentiation and Carcinogenesis

1
Programa de Recerca en Càncer, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain
2
Vall d’Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain
3
Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, D-81377 München, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Muller Fabbri
Received: 9 February 2017 / Revised: 24 March 2017 / Accepted: 24 March 2017 / Published: 30 March 2017
(This article belongs to the Special Issue Biological Methylation in Development and Cancer)
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Abstract

Histone modifications regulate chromatin structure, gene transcription, and other nuclear processes. Among the histone modifications, methylation has been considered to be a stable, irreversible process due to the slow turnover of methyl groups in chromatin. However, the discovery of three different classes of lysine-specific demethylases—KDM1, Jumonji domain-containing demethylases, and lysyl oxidase-like 2 protein—has drastically changed this view, suggesting a role for dynamic histone methylation in different biological process. In this review, we describe the different mechanisms that these enzymes use to remove lysine histone methylation and discuss their role during physiological (cell differentiation) and pathological (carcinogenesis) processes. View Full-Text
Keywords: epigenetics; histone demethylases; cellular differentiation; cancer epigenetics; histone demethylases; cellular differentiation; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Verde, G.; Querol-Paños, J.; Cebrià-Costa, J.P.; Pascual-Reguant, L.; Serra-Bardenys, G.; Iturbide, A.; Peiró, S. Lysine-Specific Histone Demethylases Contribute to Cellular Differentiation and Carcinogenesis. Epigenomes 2017, 1, 4.

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