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Insects 2016, 7(4), 58; doi:10.3390/insects7040058

Genome Investigations of Vector Competence in Aedes aegypti to Inform Novel Arbovirus Disease Control Approaches

1
Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA
2
Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Walter Tabachnick
Received: 9 September 2016 / Revised: 24 October 2016 / Accepted: 25 October 2016 / Published: 30 October 2016
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Abstract

Dengue (DENV), yellow fever, chikungunya, and Zika virus transmission to humans by a mosquito host is confounded by both intrinsic and extrinsic variables. Besides virulence factors of the individual arboviruses, likelihood of virus transmission is subject to variability in the genome of the primary mosquito vector, Aedes aegypti. The “vectorial capacity” of A. aegypti varies depending upon its density, biting rate, and survival rate, as well as its intrinsic ability to acquire, host and transmit a given arbovirus. This intrinsic ability is known as “vector competence”. Based on whole transcriptome analysis, several genes and pathways have been predicated to have an association with a susceptible or refractory response in A. aegypti to DENV infection. However, the functional genomics of vector competence of A. aegypti is not well understood, primarily due to lack of integrative approaches in genomic or transcriptomic studies. In this review, we focus on the present status of genomics studies of DENV vector competence in A. aegypti as limited information is available relative to the other arboviruses. We propose future areas of research needed to facilitate the integration of vector and virus genomics and environmental factors to work towards better understanding of vector competence and vectorial capacity in natural conditions. View Full-Text
Keywords: Aedes aegypti; vector competence; mosquito arbovirus interaction; dengue virus; transcriptome; functional genomics; integrative approach; innate immunity; genetic control Aedes aegypti; vector competence; mosquito arbovirus interaction; dengue virus; transcriptome; functional genomics; integrative approach; innate immunity; genetic control
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Severson, D.W.; Behura, S.K. Genome Investigations of Vector Competence in Aedes aegypti to Inform Novel Arbovirus Disease Control Approaches. Insects 2016, 7, 58.

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