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Insects 2015, 6(1), 236-278; doi:10.3390/insects6010236

Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes

MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, Scotland, UK
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Author to whom correspondence should be addressed.
Academic Editor: C. Roxanne Connelly
Received: 17 December 2014 / Revised: 18 February 2015 / Accepted: 10 March 2015 / Published: 23 March 2015
(This article belongs to the Special Issue Mosquito Control)
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Abstract

Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of biological approaches, both natural or engineered, to limit mosquito vector competence for arboviruses. The study of mosquito antiviral immunity has led to the identification of a number of host response mechanisms and proteins that are required to control arbovirus replication in mosquitoes, though more factors influencing vector competence are likely to be discovered. We will discuss key aspects of these pathways as targets either for selection of naturally resistant mosquito populations or for mosquito genetic manipulation. Moreover, we will consider the use of endosymbiotic bacteria such as Wolbachia, which in some cases have proven to be remarkably efficient in disrupting arbovirus transmission by mosquitoes, but also the use of naturally occurring insect-specific viruses that may interfere with arboviruses in mosquito vectors. Finally, we will discuss the use of paratransgenesis as well as entomopathogenic fungi, which are also proposed strategies to control vector competence. View Full-Text
Keywords: arbovirus; Aedes; vector control; vector competence; antiviral defences; mosquito engineering; bacteria; insect-specific viruses; paratransgenesis arbovirus; Aedes; vector control; vector competence; antiviral defences; mosquito engineering; bacteria; insect-specific viruses; paratransgenesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kean, J.; Rainey, S.M.; McFarlane, M.; Donald, C.L.; Schnettler, E.; Kohl, A.; Pondeville, E. Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes. Insects 2015, 6, 236-278.

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