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Host-Seeking Behavior in the Bed Bug, Cimex lectularius
Insects 2011, 2(1), 36-48; doi:10.3390/insects2010036
Review

Metabolic Resistance in Bed Bugs

1
,
2
 and
1,*
Received: 11 February 2011 / Revised: 10 March 2011 / Accepted: 16 March 2011 / Published: 18 March 2011
(This article belongs to the Special Issue Bed Bugs: An Emerging Pandemic)
View Full-Text   |   Download PDF [152 KB, 11 July 2011; original version 18 March 2011]

Abstract

Blood-feeding insects have evolved resistance to various insecticides (organochlorines, pyrethroids, carbamates, etc.) through gene mutations and increased metabolism. Bed bugs (Cimex lectularius) are hematophagous ectoparasites that are poised to become one of the major pests in households throughout the United States. Currently, C. lectularius has attained a high global impact status due to its sudden and rampant resurgence. Resistance to pesticides is one factor implicated in this phenomenon. Although much emphasis has been placed on target sensitivity, little to no knowledge is available on the role of key metabolic players (e.g., cytochrome P450s and glutathione S-transferases) towards pesticide resistance in C. lectularius. In this review, we discuss different modes of resistance (target sensitivity, penetration resistance, behavioral resistance, and metabolic resistance) with more emphasis on metabolic resistance.
Keywords: Cimex lectularius; insecticides; metabolic resistance; cytochrome P450; glutathione S-transferase Cimex lectularius; insecticides; metabolic resistance; cytochrome P450; glutathione S-transferase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mamidala, P.; Jones, S.C.; Mittapalli, O. Metabolic Resistance in Bed Bugs. Insects 2011, 2, 36-48.

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