Insects 2011, 2(1), 36-48; doi:10.3390/insects2010036
Review

Metabolic Resistance in Bed Bugs

1 Department of Entomology, The Ohio State University, Ohio Agricultural and Research Development Center, Wooster, OH 44691, USA 2 Department of Entomology, The Ohio State University, Columbus, OH 43210, USA
* Author to whom correspondence should be addressed.
Received: 11 February 2011; in revised form: 10 March 2011 / Accepted: 16 March 2011 / Published: 18 March 2011
(This article belongs to the Special Issue Bed Bugs: An Emerging Pandemic)
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Abstract: Blood-feeding insects have evolved resistance to various insecticides (organochlorines, pyrethroids, carbamates, etc.) through gene mutations and increased metabolism. Bed bugs (Cimex lectularius) are hematophagous ectoparasites that are poised to become one of the major pests in households throughout the United States. Currently, C. lectularius has attained a high global impact status due to its sudden and rampant resurgence. Resistance to pesticides is one factor implicated in this phenomenon. Although much emphasis has been placed on target sensitivity, little to no knowledge is available on the role of key metabolic players (e.g., cytochrome P450s and glutathione S-transferases) towards pesticide resistance in C. lectularius. In this review, we discuss different modes of resistance (target sensitivity, penetration resistance, behavioral resistance, and metabolic resistance) with more emphasis on metabolic resistance.
Keywords: Cimex lectularius; insecticides; metabolic resistance; cytochrome P450; glutathione S-transferase

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MDPI and ACS Style

Mamidala, P.; Jones, S.C.; Mittapalli, O. Metabolic Resistance in Bed Bugs. Insects 2011, 2, 36-48.

AMA Style

Mamidala P, Jones SC, Mittapalli O. Metabolic Resistance in Bed Bugs. Insects. 2011; 2(1):36-48.

Chicago/Turabian Style

Mamidala, Praveen; Jones, Susan C.; Mittapalli, Omprakash. 2011. "Metabolic Resistance in Bed Bugs." Insects 2, no. 1: 36-48.

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