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J. Pers. Med. 2015, 5(2), 83-90; doi:10.3390/jpm5020083

Neurocognitive Outcomes and School Performance in Solid Tumor Cancer Survivors Lacking Therapy to the Central Nervous System

Washington University School of Medicine, 1 Children's Place, Campus Box 8116 Saint Louis, MO 63110, USA
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Academic Editor: Jane M. Armer
Received: 16 December 2014 / Revised: 27 March 2015 / Accepted: 8 April 2015 / Published: 10 April 2015
(This article belongs to the Special Issue Long-term Cancer Survivorship)
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Abstract

School performance in patients who have received therapy for childhood cancers has been studied in depth. Risk factors have historically included cranial radiation, intrathecal chemotherapy, and high doses of chemotherapy, including methotrexate and cytarabine. Leukemia and brain tumor survivors who receive such therapy have been the primary focus of this area of investigation. Extracranial solid tumor cancer patients lacking such risk factors have historically been expected to have normal school performance. We examined the medical records of 58 young pediatric extracranial solid tumor patients who lacked CNS-directed therapy or other known risk factors for cognitive impairment to evaluate the incidence of reported difficulties or abnormalities in neuropsychological testing. Thirty-one percent of patients were found to have at least one reported difficulty or abnormality. Of note, 34% of patients with Wilms tumor possessed difficulties compared to 23% of patients with other extracranial solid tumors. Extracranial solid tumor cancer survivors without known risk factors for school performance difficulties appear to have a higher incidence of problems than expected. View Full-Text
Keywords: young children; solid tumors; neurocognitive; school performance; neuropsychological testing young children; solid tumors; neurocognitive; school performance; neuropsychological testing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mohrmann, C.; Henry, J.; Hauff, M.; Hayashi, R.J. Neurocognitive Outcomes and School Performance in Solid Tumor Cancer Survivors Lacking Therapy to the Central Nervous System. J. Pers. Med. 2015, 5, 83-90.

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