Next Generation Sequencing As an Aid to Diagnosis and Treatment of an Unusual Pediatric Brain Cancer
AbstractClassification of pediatric brain tumors with unusual histologic and clinical features may be a diagnostic challenge to the pathologist. We present a case of a 12-year-old girl with a primary intracranial tumor. The tumor classification was not certain initially, and the site of origin and clinical behavior were unusual. Genomic characterization of the tumor using a Clinical Laboratory Improvement Amendment (CLIA)-certified next-generation sequencing assay assisted in the diagnosis and translated into patient benefit, albeit transient. Our case argues that next generation sequencing may play a role in the pathological classification of pediatric brain cancers and guiding targeted therapy, supporting additional studies of genetically targeted therapeutics. View Full-Text
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Glod, J.; Song, M.; Sharma, A.; Tyagi, R.; Rhodes, R.H.; Weissmann, D.J.; Roychowdhury, S.; Khan, A.; Kane, M.P.; Hirshfield, K.; Ganesan, S.; DiPaola, R.S.; Rodriguez-Rodriguez, L. Next Generation Sequencing As an Aid to Diagnosis and Treatment of an Unusual Pediatric Brain Cancer. J. Pers. Med. 2014, 4, 402-411.
Glod J, Song M, Sharma A, Tyagi R, Rhodes RH, Weissmann DJ, Roychowdhury S, Khan A, Kane MP, Hirshfield K, Ganesan S, DiPaola RS, Rodriguez-Rodriguez L. Next Generation Sequencing As an Aid to Diagnosis and Treatment of an Unusual Pediatric Brain Cancer. Journal of Personalized Medicine. 2014; 4(3):402-411.Chicago/Turabian Style
Glod, John; Song, Mihae; Sharma, Archana; Tyagi, Rachana; Rhodes, Roy H.; Weissmann, David J.; Roychowdhury, Sudipta; Khan, Atif; Kane, Michael P.; Hirshfield, Kim; Ganesan, Shridar; DiPaola, Robert S.; Rodriguez-Rodriguez, Lorna. 2014. "Next Generation Sequencing As an Aid to Diagnosis and Treatment of an Unusual Pediatric Brain Cancer." J. Pers. Med. 4, no. 3: 402-411.