Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
J. Pers. Med. 2014, 4(2), 282-296; doi:10.3390/jpm4020282
Article

Differential Transcriptome Profile of Peripheral White Cells to Identify Biomarkers Involved in Oxaliplatin Induced Neuropathy

1,2,†
, 3,†
, 3
, 1
, 1
 and 3,*
Received: 25 March 2014; in revised form: 21 May 2014 / Accepted: 28 May 2014 / Published: 5 June 2014
(This article belongs to the Special Issue Personalized Cancer Therapy)
View Full-Text   |   Download PDF [693 KB, uploaded 5 June 2014]
Abstract: Anticancer chemotherapy (CT) produces non-desirable effects on normal healthy cells and tissues. Oxaliplatin is widely used in the treatment of colorectal cancer and responsible for the development of sensory neuropathy in varying degrees, from complete tolerance to chronic neuropathic symptoms. We studied the differential gene expression of peripheral leukocytes in patients receiving oxaliplatin-based chemotherapy to find genes and pathways involved in oxaliplatin-induced peripheral neuropathy. Circulating white cells were obtained prior and after three cycles of FOLFOX or CAPOX chemotherapy from two groups of patients: with or without neuropathy. RNA was purified, and transcriptomes were analyzed. Differential transcriptomics revealed a total of 502 genes, which were significantly up- or down-regulated as a result of chemotherapy treatment. Nine of those genes were expressed in only one of two situations: CSHL1, GH1, KCMF1, IL36G and EFCAB8 turned off after CT, and CSRP2, IQGAP1, GNRH2, SMIM1 and C5orf17 turned on after CT. These genes are likely to be associated with the onset of oxaliplatin-induced peripheral neuropathy. The quantification of their expression in peripheral white cells may help to predict non-desirable side effects and, consequently, allow a better, more personalized chemotherapy.
Keywords: transcriptome profile; chemotherapy; oxaliplatin; neuropathy; FOLFOX; CAPOX; colon-adenocarcinoma transcriptome profile; chemotherapy; oxaliplatin; neuropathy; FOLFOX; CAPOX; colon-adenocarcinoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Morales, M.; Ávila, J.; González-Fernández, R.; Boronat, L.; Soriano, M.L.; Martín-Vasallo, P. Differential Transcriptome Profile of Peripheral White Cells to Identify Biomarkers Involved in Oxaliplatin Induced Neuropathy. J. Pers. Med. 2014, 4, 282-296.

AMA Style

Morales M, Ávila J, González-Fernández R, Boronat L, Soriano ML, Martín-Vasallo P. Differential Transcriptome Profile of Peripheral White Cells to Identify Biomarkers Involved in Oxaliplatin Induced Neuropathy. Journal of Personalized Medicine. 2014; 4(2):282-296.

Chicago/Turabian Style

Morales, Manuel; Ávila, Julio; González-Fernández, Rebeca; Boronat, Laia; Soriano, María L.; Martín-Vasallo, Pablo. 2014. "Differential Transcriptome Profile of Peripheral White Cells to Identify Biomarkers Involved in Oxaliplatin Induced Neuropathy." J. Pers. Med. 4, no. 2: 282-296.

J. Pers. Med. EISSN 2075-4426 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert