Special Issue "Personalized Cancer Therapy"
A special issue of Journal of Personalized Medicine (ISSN 2075-4426).
Deadline for manuscript submissions: closed (31 March 2014)
Dr. Roy S. Herbst
Yale Cancer Center, Section of Medical Oncology, 33 Cedar Street, PO Box 208028, New Haven, CT, USA
Interests: early phase clinical trials; biomarker studies; personalized medicine for cancer treatment
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
Review: Non-Small Cell Lung Cancer beyond Biomarkers: The Evolving Landscape of Clinical Trial Design
J. Pers. Med. 2014, 4(3), 386-401; doi:10.3390/jpm4030386
Received: 26 March 2014; in revised form: 10 June 2014 / Accepted: 13 June 2014 / Published: 30 June 2014| PDF Full-text (467 KB) | HTML Full-text | XML Full-text
J. Pers. Med. 2014, 4(3), 297-310; doi:10.3390/jpm4030297
Received: 27 March 2014; in revised form: 15 April 2014 / Accepted: 4 June 2014 / Published: 25 June 2014| PDF Full-text (464 KB) | HTML Full-text | XML Full-text
Article: Differential Transcriptome Profile of Peripheral White Cells to Identify Biomarkers Involved in Oxaliplatin Induced Neuropathy
J. Pers. Med. 2014, 4(2), 282-296; doi:10.3390/jpm4020282
Received: 25 March 2014; in revised form: 21 May 2014 / Accepted: 28 May 2014 / Published: 5 June 2014| PDF Full-text (693 KB) | HTML Full-text | XML Full-text | Supplementary Files
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Original research article
Tentative Title: A Cross-Disciplinary Analysis of Personalized Outcomes and Prioritized Areas of Concern in a Pragmatic Intervention Trial
Authors: Christina Gundgaard Pedersen (Corresponding author) (1), Nina Nissen (2), Marzcia Techau (2), Helle Johannessen (2), Jacob v.B. Hjelmborg (3), Rita Agdal (2), Robert Zachariae (1), Jan Sørensen (4), Anders Green (5), Anita Lunde (2), Ann Ostenfeldt-Rosenthal (2)
Affiliations:1 Unit of Psychooncology and Health Psychology, Department of Oncology, Aarhus University Hospital & Department of Psychology, Aarhus University, Bartholins Allé 9, 8000 Aarhus C
2 Health, Man and Society, Institute of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9B, 5000 Odense C, Denmark3 Department of Biostatistics, Institute of Public Health, University of Southern Denmark, J.B.Winsløws Vej 9B, 5000 Odense C, Denmark
4 Centre for Applied Health Services Research, Institute of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9B, 5000 Odense C, Denmark
5 Odense Patient Data Explorative Network (OPEN), Institute of Clinical Research, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
Abstract: Purpose: The objective was to explore a cross-disciplinary analysis of personalized outcomes and prioritized areas of concern in a manner that acknowledged all disciplines equally in a pragmatic healing intervention trial among patients treated for colorectal cancer. Specifically, it was examined: 1) if there was consistency between personalized outcome areas and prioritized areas of concern identified in questionnaires and interviews respectively, and, 2) if there was consistency between the disciplines in the type and observed change reported in interviews or on measures related to the identified personalized outcome areas and/or prioritized areas of concern.
Methods: 29 patients treated for colorectal cancer and part of a pragmatic healing intervention trial were interviewed and completed questionnaires assessing quality of life (QoL), depressive symptoms, mood, sleep quality, physical activity (supplemented by physical activity), physical fitness, and late effects at baseline, 1 week, and 2 months post-intervention. They also indicated personalized outcome areas and prioritized areas of concern. Reliable change indices were calculated for relevant outcome data to promote a cross-disciplinary analysis process emphasizing equality between disciplines. A multidisciplinary, interdisciplinary, and transdisciplinary iterative process sought to inform patterns and continued until no new information was gained from the process.
Results: Consistency in topics in focus was found for the majority of participants (N=20/68.9 ). A total of 4 (20 %) of those in intervention group experienced significant reliable changes in their personal outcome areas and 7 (35 %) experienced changes in relation to their prioritized areas of concern. Inconsistency between disciplines (psychology, biology, and anthropology) in type and observed change in personalized outcome areas and/or prioritized areas of concern was found for 10 (41.4 %) in intervention group and 3 (10.3) in control. Inconsistencies were related to only interviews observing changes identified as soft non-specific changes.
Conclusion: A cross-disciplinary iterative process with equality between disciplines was found useful but time consuming method for analyzing experienced changes in relation to personalized outcomes and/or prioritized areas of concern and for identifying patterns of experienced changes in relation to individualized treatment. However, implementation of personalized outcomes requires that participants are guided to realistic expectations in relation to outcomes of unfamiliar interventions, where prioritizing areas of concern was found a useful method in relation to identifying relevant standardized measures. Calculation of reliable change indices was found a useful means of qualitizing quantitative outcomes for triangulation at the individual level.
Last update: 23 January 2014