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J. Pers. Med. 2012, 2(2), 50-70; doi:10.3390/jpm2020050

Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies

1
Département de microbiologie-infectiologie et d'immunologie, Faculté de médecine, Université Laval, Centre de recherche du CHUQ, 2705 Laurier blvd., Québec City (Québec), G1V 4G2, Canada
2
Centre de recherche en infectiologie de l'Université Laval, Centre de recherche du CHUQ, 2705 Laurier blvd., Québec City (Québec), G1V 4G2, Canada
*
Author to whom correspondence should be addressed.
Received: 12 March 2012 / Revised: 13 April 2012 / Accepted: 28 April 2012 / Published: 2 May 2012
(This article belongs to the Special Issue Recent Advances in Personalized Medicine)
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Abstract

Infectious disease management essentially consists in identifying the microbial cause(s) of an infection, initiating if necessary antimicrobial therapy against microbes, and controlling host reactions to infection. In clinical microbiology, the turnaround time of the diagnostic cycle (>24 hours) often leads to unnecessary suffering and deaths; approaches to relieve this burden include rapid diagnostic procedures and more efficient transmission or interpretation of molecular microbiology results. Although rapid nucleic acid-based diagnostic testing has demonstrated that it can impact on the transmission of hospital-acquired infections, we believe that such life-saving procedures should be performed closer to the patient, in dedicated 24/7 laboratories of healthcare institutions, or ideally at point of care. While personalized medicine generally aims at interrogating the genomic information of a patient, drug metabolism polymorphisms, for example, to guide drug choice and dosage, personalized medicine concepts are applicable in infectious diseases for the (rapid) identification of a disease-causing microbe and determination of its antimicrobial resistance profile, to guide an appropriate antimicrobial treatment for the proper management of the patient. The implementation of point-of-care testing for infectious diseases will require acceptance by medical authorities, new technological and communication platforms, as well as reimbursement practices such that time- and life-saving procedures become available to the largest number of patients. View Full-Text
Keywords: infectious diseases; molecular diagnostics; point-of-care; personalized medicine infectious diseases; molecular diagnostics; point-of-care; personalized medicine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bissonnette, L.; Bergeron, M.G. Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies. J. Pers. Med. 2012, 2, 50-70.

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