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Diagnostics 2017, 7(2), 19; doi:10.3390/diagnostics7020019

Ovarian Cancer Incidence Corrected for Oophorectomy

1
The Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Kentucky College of Medicine, 800 Rose Street, 330 Whitney-Hendrickson Building, Lexington, KY 40536, USA
2
Division of Cancer Biostatistics, College of Public Health & Biostatistics Shared Resource Facility, Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA
3
Department of Epidemiology, College of Public Health & Kentucky Cancer Registry, Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA
4
Kentucky Department for Public Health, Frankfort, KY 40601, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Tanya W. Moseley
Received: 30 December 2016 / Revised: 1 March 2017 / Accepted: 18 March 2017 / Published: 1 April 2017
(This article belongs to the Special Issue Ovarian Cancer Screening)
View Full-Text   |   Download PDF [379 KB, uploaded 1 April 2017]   |  

Abstract

Current reported incidence rates for ovarian cancer may significantly underestimate the true rate because of the inclusion of women in the calculations who are not at risk for ovarian cancer due to prior benign salpingo-oophorectomy (SO). We have considered prior SO to more realistically estimate risk for ovarian cancer. Kentucky Health Claims Data, International Classification of Disease 9 (ICD-9) codes, Current Procedure Terminology (CPT) codes, and Kentucky Behavioral Risk Factor Surveillance System (BRFSS) Data were used to identify women who have undergone SO in Kentucky, and these women were removed from the at-risk pool in order to re-assess incidence rates to more accurately represent ovarian cancer risk. The protective effect of SO on the population was determined on an annual basis for ages 5–80+ using data from the years 2009–2013. The corrected age-adjusted rates of ovarian cancer that considered SO ranged from 33% to 67% higher than age-adjusted rates from the standard population. Correction of incidence rates for ovarian cancer by accounting for women with prior SO gives a better understanding of risk for this disease faced by women. The rates of ovarian cancer were substantially higher when SO was taken into consideration than estimates from the standard population. View Full-Text
Keywords: ovarian cancer; prevalence; incidence; oophorectomy; screening ovarian cancer; prevalence; incidence; oophorectomy; screening
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Baldwin, L.A.; Chen, Q.; Tucker, T.C.; White, C.G.; Ore, R.N.; Huang, B. Ovarian Cancer Incidence Corrected for Oophorectomy. Diagnostics 2017, 7, 19.

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