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Diagnostics 2017, 7(1), 18; doi:10.3390/diagnostics7010018

Symptoms Relevant to Surveillance for Ovarian Cancer

1
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Chandler Medical Center-Markey Cancer Center, Lexington, KY 40536-0293, USA
2
Department of Statistics, University of Kentucky Chandler Medical Center-Markey Cancer Center, Lexington, KY 40536-0293, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Andreas Kjaer
Received: 13 December 2016 / Revised: 1 March 2017 / Accepted: 13 March 2017 / Published: 20 March 2017
(This article belongs to the Special Issue Ovarian Cancer Screening)
View Full-Text   |   Download PDF [409 KB, uploaded 21 March 2017]   |  

Abstract

To examine how frequently and confidently healthy women report symptoms during surveillance for ovarian cancer. A symptoms questionnaire was administered to 24,526 women over multiple visits accounting for 70,734 reports. A query of reported confidence was included as a confidence score (CS). Chi square, McNemars test, ANOVA and multivariate analyses were performed. 17,623 women completed the symptoms questionnaire more than one time and >9500 women completed it more than one four times for >43,000 serially completed questionnaires. Reporting ovarian cancer symptoms was ~245 higher than ovarian cancer incidence. The positive predictive value (0.073%) for identifying ovarian cancer based on symptoms alone would predict one malignancy for 1368 cases taken to surgery due to reported symptoms. Confidence on the first questionnaire (83.3%) decreased to 74% when more than five questionnaires were completed. Age-related decreases in confidence were significant (p < 0.0001). Women reporting at least one symptom expressed more confidence (41,984/52,379 = 80.2%) than women reporting no symptoms (11,882/18,355 = 64.7%), p < 0.0001. Confidence was unrelated to history of hormone replacement therapy or abnormal ultrasound findings (p = 0.30 and 0.89). The frequency of symptoms relevant to ovarian cancer was much higher than the occurrence of ovarian cancer. Approximately 80.1% of women expressed confidence in what they reported. View Full-Text
Keywords: symptoms; questionnaire; certainty/uncertainty symptoms; questionnaire; certainty/uncertainty
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MDPI and ACS Style

Ore, R.M.; Baldwin, L.; Woolum, D.; Elliott, E.; Wijers, C.; Chen, C.-Y.; Miller, R.W.; DeSimone, C.P.; Ueland, F.R.; Kryscio, R.J.; Nagell, J.R.; Pavlik, E.J. Symptoms Relevant to Surveillance for Ovarian Cancer. Diagnostics 2017, 7, 18.

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