Prebiotic RNA Network Formation: A Taxonomy of Molecular Cooperation
AbstractCooperation is essential for evolution of biological complexity. Recent work has shown game theoretic arguments, commonly used to model biological cooperation, can also illuminate the dynamics of chemical systems. Here we investigate the types of cooperation possible in a real RNA system based on the Azoarcus ribozyme, by constructing a taxonomy of possible cooperative groups. We construct a computational model of this system to investigate the features of the real system promoting cooperation. We find triplet interactions among genotypes are intrinsically biased towards cooperation due to the particular distribution of catalytic rate constants measured empirically in the real system. For other distributions cooperation is less favored. We discuss implications for understanding cooperation as a driver of complexification in the origin of life. View Full-Text
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Mathis, C.; Ramprasad, S.N.; Walker, S.I.; Lehman, N. Prebiotic RNA Network Formation: A Taxonomy of Molecular Cooperation. Life 2017, 7, 38.
Mathis C, Ramprasad SN, Walker SI, Lehman N. Prebiotic RNA Network Formation: A Taxonomy of Molecular Cooperation. Life. 2017; 7(4):38.Chicago/Turabian Style
Mathis, Cole; Ramprasad, Sanjay N.; Walker, Sara I.; Lehman, Niles. 2017. "Prebiotic RNA Network Formation: A Taxonomy of Molecular Cooperation." Life 7, no. 4: 38.
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