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Life 2016, 6(2), 15; doi:10.3390/life6020015

tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World

1,†,* , 2,†
and
3,†,*
1
Laboratório de Genética Evolutiva Paulo Leminsk, Departamento de Biologia Molecular, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil
2
Departamento de Informática, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil
3
Theoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México 04510, Mexico
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Lluís Ribas de Pouplana and David Deamer
Received: 28 August 2015 / Revised: 29 February 2016 / Accepted: 18 March 2016 / Published: 23 March 2016
(This article belongs to the Special Issue Evolution of tRNA)
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Abstract

Herein we present the tRNA core hypothesis, which emphasizes the central role of tRNAs molecules in the origin and evolution of fundamental biological processes. tRNAs gave origin to the first genes (mRNA) and the peptidyl transferase center (rRNA), proto-tRNAs were at the core of a proto-translation system, and the anticodon and operational codes then arose in tRNAs molecules. Metabolic pathways emerged from evolutionary pressures of the decoding systems. The transitions from the RNA world to the ribonucleoprotein world to modern biological systems were driven by three kinds of tRNAs transitions, to wit, tRNAs leading to both mRNA and rRNA. View Full-Text
Keywords: tRNA; origin of life; translation system; ribosome tRNA; origin of life; translation system; ribosome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

de Farias, S.T.; Rêgo, T.G.; José, M.V. tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World. Life 2016, 6, 15.

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