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Life 2016, 6(2), 16; doi:10.3390/life6020016

Multiple Layers of Stress-Induced Regulation in tRNA Biology

Department of Biology, Indiana University, 915 E third St., Myers 300, Bloomington, IN 47405, USA
Department of Molecular Genetics and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Academic Editors: Lluís Ribas de Pouplana and David Deamer
Received: 25 January 2016 / Revised: 14 March 2016 / Accepted: 17 March 2016 / Published: 23 March 2016
(This article belongs to the Special Issue Evolution of tRNA)
View Full-Text   |   Download PDF [788 KB, uploaded 23 March 2016]   |  


tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating apoptosis and several other biological processes. There are multiple layers of regulatory mechanisms in each step of tRNA biogenesis. For example, tRNA 3′ trailer processing is altered upon nutrient stress; tRNA modification is reprogrammed under various stresses; nuclear accumulation of tRNAs occurs upon nutrient deprivation; tRNA halves accumulate upon oxidative stress. Here we address how environmental stresses can affect nearly every step of tRNA biology and we describe the possible regulatory mechanisms that influence the function or expression of tRNAs under stress conditions. View Full-Text
Keywords: tRNA processing; tRNA subcellular dynamics; tRNA modification; tRNA fragments tRNA processing; tRNA subcellular dynamics; tRNA modification; tRNA fragments

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Huang, H.-Y.; Hopper, A.K. Multiple Layers of Stress-Induced Regulation in tRNA Biology. Life 2016, 6, 16.

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