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Life 2013, 3(3), 386-402; doi:10.3390/life3030386
Article

Phosphate Activation via Reduced Oxidation State Phosphorus (P). Mild Routes to Condensed-P Energy Currency Molecules

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Received: 14 May 2013; in revised form: 8 June 2013 / Accepted: 13 June 2013 / Published: 19 July 2013
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Abstract: The emergence of mechanisms for phosphorylating organic and inorganic molecules is a key step en route to the earliest living systems. At the heart of all contemporary biochemical systems reside reactive phosphorus (P) molecules (such as adenosine triphosphate, ATP) as energy currency molecules to drive endergonic metabolic processes and it has been proposed that a predecessor of such molecules could have been pyrophosphate [P2O74−; PPi(V)]. Arguably the most geologically plausible route to PPi(V) is dehydration of orthophosphate, Pi(V), normally a highly endergonic process in the absence of mechanisms for activating Pi(V). One possible solution to this problem recognizes the presence of reactive-P containing mineral phases, such as schreibersite [(Fe,Ni)3P] within meteorites whose abundance on the early Earth would likely have been significant during a putative Hadean-Archean heavy bombardment. Here, we propose that the reduced oxidation state P-oxyacid, H-phosphite [HPO32−; Pi(III)] could have activated Pi(V) towards condensation via the intermediacy of the condensed oxyacid pyrophosphite [H2P2O52−; PPi(III)]. We provide geologically plausible provenance for PPi(III) along with evidence of its ability to activate Pi(V) towards PPi(V) formation under mild conditions (80 °C) in water.
Keywords: phosphorus; prebiotic chemistry; origin of life; meteorites phosphorus; prebiotic chemistry; origin of life; meteorites
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kee, T.P.; Bryant, D.E.; Herschy, B.; Marriott, K.E.R.; Cosgrove, N.E.; Pasek, M.A.; Atlas, Z.D.; Cousins, C.R. Phosphate Activation via Reduced Oxidation State Phosphorus (P). Mild Routes to Condensed-P Energy Currency Molecules. Life 2013, 3, 386-402.

AMA Style

Kee TP, Bryant DE, Herschy B, Marriott KER, Cosgrove NE, Pasek MA, Atlas ZD, Cousins CR. Phosphate Activation via Reduced Oxidation State Phosphorus (P). Mild Routes to Condensed-P Energy Currency Molecules. Life. 2013; 3(3):386-402.

Chicago/Turabian Style

Kee, Terence P.; Bryant, David E.; Herschy, Barry; Marriott, Katie E.R.; Cosgrove, Nichola E.; Pasek, Matthew A.; Atlas, Zachary D.; Cousins, Claire R. 2013. "Phosphate Activation via Reduced Oxidation State Phosphorus (P). Mild Routes to Condensed-P Energy Currency Molecules." Life 3, no. 3: 386-402.



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