Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review
Abstract
:1. Introduction
2. Results
2.1. Patient Background and Pain Assessment
2.2. Opioid Analgesic Required for Postoperative Pain
3. Discussion
4. Materials and Methods
4.1. Participants
4.2. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- De Cosmo, G.; Aceto, P.; Gualtieri, E.; Congedo, E. Analgesia in thoracic surgery: Review. Minerva Anesthesiol. 2009, 75, 393–400. [Google Scholar]
- Pisani, M.A.; Kong, S.Y.; Kasl, S.V.; Murphy, T.E.; Araujo, K.L.; Van Ness, P.H. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am. J. Resp. Crit. Care Med. 2009, 180, 1092–1097. [Google Scholar] [CrossRef] [PubMed]
- Bartels, K.; Mayes, L.M.; Dingmann, C.; Bullard, K.J.; Hopfer, C.J.; Binswanger, I.A. Opioid use and storage patterns by patients after hospital discharge following surgery. PLoS ONE 2016, 11, e0147972. [Google Scholar] [CrossRef] [PubMed]
- Inoue, K. The function of microglia through purinergic receptors: Neuropathic pain and cytokine release. Pharmacol. Ther. 2006, 109, 210–226. [Google Scholar] [CrossRef] [PubMed]
- Inoue, K. Microglial activation by purines and pyrimidines. Glia 2002, 40, 156–163. [Google Scholar] [CrossRef] [PubMed]
- Haynes, S.E.; Hollopeter, G.; Yang, G.; Kurpis, D.; Dailey, M.E.; Gan, W.B.; Julius, D. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat. Neurosci. 2006, 9, 1512–1519. [Google Scholar] [CrossRef] [PubMed]
- Sumitani, M.; Nishizawa, D.; Nagashima, M.; Ikeda, K.; Abe, H.; Kato, R.; Ueda, H.; Yamada, Y. Japanese TR-Cancer Pain research group. Association Between Polymorphisms in the Purinergic P2Y12 Receptor Gene and Severity of Both Cancer Pain and Postoperative Pain. Pain Med. 2018, 19, 348–354. [Google Scholar] [CrossRef] [PubMed]
- Miura, G.; Ariyoshi, N.; Sato, Y.; Yamaguchi, H.; Iwata, Y.; Fujimoto, Y.; Kobayashi, Y.; Ishii, I. Genetic and non-genetic factors responsible for antiplatelet effects of clopidogrel in Japanese patients undergoing coronary stent implantation: An algorithm to predict on-clopidogrel platelet reactivity. Thromb. Res. 2014, 134, 877–883. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Inoue, K.; Tsuda, M. Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential. Nat. Rev. Neurosci. 2018, 19, 138–152. [Google Scholar] [CrossRef]
- Yu, T.; Zhang, X.; Shi, H.; Tian, J.; Sun, L.; Hu, X.; Cui, W.; Du, D. P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents. Cell Death Dis. 2019, 10, 165–181. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Lori, N.E.; Anne, Z.M. Inflammatory Mediators of Opioid Tolerance: Implications for Dependency and Addiction. Peptides 2019, 115, 51–58. [Google Scholar]
- Kolesnikov, Y.; Gabovits, B.; Levin, A.; Voiko, E.; Veske, A. Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects. Anesth. Analg. 2011, 112, 448–453. [Google Scholar] [CrossRef] [PubMed]
- Campa, D.; Gioia, A.; Tomei, A.; Poli, P.; Barale, R. Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin. Pharmacol. Ther. 2008, 83, 559–566. [Google Scholar] [CrossRef]
- Busch, R.; Neese, R.A.; Awada, M.; Hayes, G.M.; Hellerstein, M.K. Measurement of cell proliferation by heavy water labeling. Nat. Protoc. 2007, 2, 3045–3057. [Google Scholar] [CrossRef]
- Macallan, D.C.; Wallace, D.L.; Zhang, Y.; Ghattas, H.; Asquith, B.; de Lara, C.; Worth, A.; Panayiotakopoulos, G.; Griffin, G.E.; Tough, D.F.; et al. B-cell kinetics in humans: Rapid turn over of peripheral blood memory cells. Blood 2005, 105, 3633–3640. [Google Scholar] [CrossRef]
- Tay, T.L.; Mai, D.; Dautzenberg, J.; Fernandez-Klett, F.; Lin, G.; Datta, M.; Drougard, A.; Stempfl, T.; Ardura-Fabregat, A.; Staszewski, O.; et al. A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nat. Neurosci. 2017, 20, 793–803. [Google Scholar] [CrossRef] [PubMed]
- Pravix®, Ethical Drug Package Insert by Japanese Pharmaceuticals and Medical Devices Agency. Available online: https://www.info.pmda.go.jp/go/pack/3399008F1025_1_26/?view=frame&style=XML&lang=ja (accessed on 3 April 2020). (In Japanese).
- Tozaki-Saitoh, H.; Tsuda, M.; Miyata, H.; Ueda, K.; Kohsaka, S.; Inoue, K. P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. J. Neurosci. 2008, 28, 4949–4956. [Google Scholar] [CrossRef]
Groups | Male (%) | Age | BMI (Body Mass Index) | NSAIDs (%) |
---|---|---|---|---|
ASP group (N = 17) | 94 | 74 | 22.9 | 60 |
CLP group (N = 10) | 90 | 75 | 24.2 | 65 |
P-value | 0.99 | 0.90 | 0.75 | 0.99 |
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Tsuchida, R.; Sumitani, M.; Abe, H.; Ando, M.; Saita, K.; Hattori, K.; Mietani, K.; Inoue, R.; Uchida, K. Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review. Life 2020, 10, 92. https://doi.org/10.3390/life10060092
Tsuchida R, Sumitani M, Abe H, Ando M, Saita K, Hattori K, Mietani K, Inoue R, Uchida K. Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review. Life. 2020; 10(6):92. https://doi.org/10.3390/life10060092
Chicago/Turabian StyleTsuchida, Rikuhei, Masahiko Sumitani, Hiroaki Abe, Masae Ando, Kosuke Saita, Kohshi Hattori, Kazuhito Mietani, Reo Inoue, and Kanji Uchida. 2020. "Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review" Life 10, no. 6: 92. https://doi.org/10.3390/life10060092