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Antibodies 2015, 4(3), 170-196; doi:10.3390/antib4030170

Opportunities for Conformation-Selective Antibodies in Amyloid-Related Diseases

Structural Biology, UCB, 216 Bath Road, Slough, SL1 3WE UK
Author to whom correspondence should be addressed.
Academic Editor: Dimiter S. Dimitrov
Received: 13 May 2015 / Revised: 5 July 2015 / Accepted: 9 July 2015 / Published: 15 July 2015
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Assembly of misfolded proteins into fibrillar deposits is a common feature of many neurodegenerative diseases. Developing effective therapies to these complex, and not yet fully understood diseases is currently one of the greatest medical challenges facing society. Slow and initially asymptomatic onset of neurodegenerative disorders requires profound understanding of the processes occurring at early stages of the disease including identification and structural characterisation of initial toxic species underlying neurodegeneration. In this review, we chart the latest progress made towards understanding the multifactorial process leading to amyloid formation and highlight efforts made in the development of therapeutic antibodies for the treatment of amyloid-based disorders. The specificity and selectivity of conformational antibodies make them attractive research probes to differentiate between transient states preceding formation of mature fibrils and enable strategies for potential therapeutic intervention to be considered. View Full-Text
Keywords: antibody; amyloids; conformation; prion; Alzheimer’s; Parkinson’s; fibrils, tau; Huntingtin; protein misfolding antibody; amyloids; conformation; prion; Alzheimer’s; Parkinson’s; fibrils, tau; Huntingtin; protein misfolding

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Westwood, M.; Lawson, A.D.G. Opportunities for Conformation-Selective Antibodies in Amyloid-Related Diseases. Antibodies 2015, 4, 170-196.

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