Next Article in Journal
Antibody Conjugates: From Heterogeneous Populations to Defined Reagents
Previous Article in Journal
Model-Based Comparison of Antibody Dimerization in Continuous and Batch-Wise Downstream Processing
Article Menu

Export Article

Open AccessReview
Antibodies 2015, 4(3), 170-196; doi:10.3390/antib4030170

Opportunities for Conformation-Selective Antibodies in Amyloid-Related Diseases

Structural Biology, UCB, 216 Bath Road, Slough, SL1 3WE UK
*
Author to whom correspondence should be addressed.
Academic Editor: Dimiter S. Dimitrov
Received: 13 May 2015 / Revised: 5 July 2015 / Accepted: 9 July 2015 / Published: 15 July 2015
View Full-Text   |   Download PDF [1054 KB, uploaded 15 July 2015]   |  

Abstract

Assembly of misfolded proteins into fibrillar deposits is a common feature of many neurodegenerative diseases. Developing effective therapies to these complex, and not yet fully understood diseases is currently one of the greatest medical challenges facing society. Slow and initially asymptomatic onset of neurodegenerative disorders requires profound understanding of the processes occurring at early stages of the disease including identification and structural characterisation of initial toxic species underlying neurodegeneration. In this review, we chart the latest progress made towards understanding the multifactorial process leading to amyloid formation and highlight efforts made in the development of therapeutic antibodies for the treatment of amyloid-based disorders. The specificity and selectivity of conformational antibodies make them attractive research probes to differentiate between transient states preceding formation of mature fibrils and enable strategies for potential therapeutic intervention to be considered. View Full-Text
Keywords: antibody; amyloids; conformation; prion; Alzheimer’s; Parkinson’s; fibrils, tau; Huntingtin; protein misfolding antibody; amyloids; conformation; prion; Alzheimer’s; Parkinson’s; fibrils, tau; Huntingtin; protein misfolding
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Westwood, M.; Lawson, A.D.G. Opportunities for Conformation-Selective Antibodies in Amyloid-Related Diseases. Antibodies 2015, 4, 170-196.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top