Next Article in Journal
The Role of CD2 Family Members in NK-Cell Regulation of B-Cell Antibody Production
Previous Article in Journal
CD20 mAb-Mediated Complement Dependent Cytotoxicity of Tumor Cells is Enhanced by Blocking the Action of Factor I
Article Menu

Export Article

Open AccessReview
Antibodies 2013, 2(4), 617-635; doi:10.3390/antib2040617

Potential for Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity for Control of Human Cytomegalovirus

Cardiff Institute of Infection and Immunity, Cardiff University, Cardiff, CF14 4XN, UK
*
Author to whom correspondence should be addressed.
Received: 31 October 2013 / Revised: 15 November 2013 / Accepted: 27 November 2013 / Published: 10 December 2013
View Full-Text   |   Download PDF [244 KB, uploaded 10 December 2013]   |  

Abstract

Human cytomegalovirus (HCMV) is an important pathogen that infects the majority of the population worldwide, yet, currently, there is no licensed vaccine. Despite HCMV encoding at least seven Natural Killer (NK) cell evasion genes, NK cells remain critical for the control of infection in vivo. Classically Antibody-Dependent Cellular Cytotoxicity (ADCC) is mediated by CD16, which is found on the surface of the NK cell in a complex with FcεRI-γ chains and/or CD3ζ chains. Ninety percent of NK cells express the Fc receptor CD16; thus, they have the potential to initiate ADCC. HCMV has a profound effect on the NK cell repertoire, such that up to 10-fold expansions of NKG2C+ cells can be seen in HCMV seropositive individuals. These NKG2C+ cells are reported to be FcεRI-γ deficient and possess variable levels of CD16+, yet have striking ADCC functions. A subset of HCMV cell surface proteins will induce robust antibody responses that could render cells susceptible to ADCC. We will consider how the strong anti-HCMV function of NKG2C+ FcεRI-γ-deficient NK cells could potentially be harnessed in the clinic to treat patients suffering from HCMV disease and in the development of an efficacious HCMV vaccine. View Full-Text
Keywords: HCMV; Cytomegalovirus; ADCC; antibody-dependent cellular cytotoxicity; NK cells; NKG2C; UL40; HLA-E; vaccine HCMV; Cytomegalovirus; ADCC; antibody-dependent cellular cytotoxicity; NK cells; NKG2C; UL40; HLA-E; vaccine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Aicheler, R.J.; Wang, E.C.Y.; Tomasec, P.; Wilkinson, G.W.G.; Stanton, R.J. Potential for Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity for Control of Human Cytomegalovirus. Antibodies 2013, 2, 617-635.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top