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Regulatory B-Cells in Transplantation
Immunology Service, Universitary Hospital Marqués de Valdecilla-IFIMAV, Avd Valdecilla s/n, Santander 39008, Spain
Nephrology Service, Universitary Hospital Marqués de Valdecilla-IFIMAV, Avd Valdecilla s/n, Santander 39008, Spain
* Author to whom correspondence should be addressed.
Received: 3 September 2013; in revised form: 22 October 2013 / Accepted: 23 October 2013 / Published: 20 November 2013
Abstract: B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production. The development of donor-specific antibodies by B-cells has deleterious consequences in graft and patients survival. Recently, a new subset of IL-10-secreting B-cells with regulatory capacity in allergic and autoimmune diseases has been shown. Such regulatory function changes the apprehension of B-cells as effector cells and increases the complexity to the immuno-regulatory networks. New therapies targeting B-cells should consider that depleting B-cells potentially impairs regulatory B-cells (Bregs) and that modulating or favoring the maintenance and function of Bregs would be important for the achievement of humoral tolerance. Unfortunately, few direct pieces of evidence of Breg involvement in allograft tolerance models has been described. Here, we summarize the current knowledge of the role of Bregs in transplantation.
Keywords: Bregs; IL-10
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MDPI and ACS Style
San Segundo, D.; López-Hoyos, M.; Arias, M. Regulatory B-Cells in Transplantation. Antibodies 2013, 2, 587-597.
San Segundo D, López-Hoyos M, Arias M. Regulatory B-Cells in Transplantation. Antibodies. 2013; 2(4):587-597.
San Segundo, David; López-Hoyos, Marcos; Arias, Manuel. 2013. "Regulatory B-Cells in Transplantation." Antibodies 2, no. 4: 587-597.