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Antibodies 2013, 2(4), 587-597; doi:10.3390/antib2040587
Review

Regulatory B-Cells in Transplantation

1
, 1,*  and 2
Received: 3 September 2013; in revised form: 22 October 2013 / Accepted: 23 October 2013 / Published: 20 November 2013
(This article belongs to the Special Issue B Cells and Immunological Tolerance)
View Full-Text   |   Download PDF [385 KB, uploaded 20 November 2013]
Abstract: B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production. The development of donor-specific antibodies by B-cells has deleterious consequences in graft and patients survival. Recently, a new subset of IL-10-secreting B-cells with regulatory capacity in allergic and autoimmune diseases has been shown. Such regulatory function changes the apprehension of B-cells as effector cells and increases the complexity to the immuno-regulatory networks. New therapies targeting B-cells should consider that depleting B-cells potentially impairs regulatory B-cells (Bregs) and that modulating or favoring the maintenance and function of Bregs would be important for the achievement of humoral tolerance. Unfortunately, few direct pieces of evidence of Breg involvement in allograft tolerance models has been described. Here, we summarize the current knowledge of the role of Bregs in transplantation.
Keywords: Bregs; IL-10 Bregs; IL-10
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

San Segundo, D.; López-Hoyos, M.; Arias, M. Regulatory B-Cells in Transplantation. Antibodies 2013, 2, 587-597.

AMA Style

San Segundo D, López-Hoyos M, Arias M. Regulatory B-Cells in Transplantation. Antibodies. 2013; 2(4):587-597.

Chicago/Turabian Style

San Segundo, David; López-Hoyos, Marcos; Arias, Manuel. 2013. "Regulatory B-Cells in Transplantation." Antibodies 2, no. 4: 587-597.

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