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Regulation of Germinal Center Reactions by B and T Cells
Center for Immunology and Autoimmune Diseases, Institute of Molecular Medicine, the University of Texas Medical School at Houston, Houston, TX 77030, USA
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
Department of Pediatrics, the University of Texas Medical School at Houston, Houston, TX 77030, USA
* Author to whom correspondence should be addressed.
Received: 9 September 2013; in revised form: 15 October 2013 / Accepted: 16 October 2013 / Published: 23 October 2013
Abstract: Break of B cell tolerance to self-antigens results in the development of autoantibodies and, thus, leads to autoimmunity. How B cell tolerance is maintained during active germinal center (GC) reactions is yet to be fully understood. Recent advances revealed several subsets of T cells and B cells that can positively or negatively regulate GC B cell responses in vivo. IL-21-producing CXCR5+ CD4+ T cells comprise a distinct lineage of helper T cells—termed follicular helper T cells (TFH)—that can provide help for the development of GC reactions where somatic hypermutation and affinity maturation take place. Although the function of TFH cells is beneficial in generating high affinity antibodies against infectious agents, aberrant activation of TFH cell or B cell to self-antigens results in autoimmunity. At least three subsets of immune cells have been proposed as regulatory cells that can limit such antibody-mediated autoimmunity, including follicular regulatory T cells (TFR), Qa-1 restricted CD8+ regulatory T cells (CD8+TREG), and regulatory B cells (BREG). In this review, we will discuss our current understanding of GC B cell regulation with specific emphasis on the newly identified immune cell subsets involved in this process.
Keywords: TFH; TFR; BREG; Qa-1 restricted CD8+TREG; Germinal center; B cells; antibody
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MDPI and ACS Style
Kim, Y.U.; Liu, X.; Tanaka, S.; Tran, D.Q.; Chung, Y. Regulation of Germinal Center Reactions by B and T Cells. Antibodies 2013, 2, 554-586.
Kim YU, Liu X, Tanaka S, Tran DQ, Chung Y. Regulation of Germinal Center Reactions by B and T Cells. Antibodies. 2013; 2(4):554-586.
Kim, Young U.; Liu, Xindong; Tanaka, Shinya; Tran, Dat Q.; Chung, Yeonseok. 2013. "Regulation of Germinal Center Reactions by B and T Cells." Antibodies 2, no. 4: 554-586.