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Genes 2018, 9(3), 127; https://doi.org/10.3390/genes9030127

Wnt Signaling in Stem Cell Maintenance and Differentiation in the Drosophila Germarium

Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA
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Received: 12 January 2018 / Revised: 13 February 2018 / Accepted: 14 February 2018 / Published: 27 February 2018
(This article belongs to the Special Issue Wnt Signaling in Stem Cells)
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Abstract

Wnt signaling is a conserved regulator of stem cell behaviors, and the Drosophila germarium has been an important model tissue for the study of stem cell maintenance, differentiation, and proliferation. Here we review Wnt signaling in the germarium, which houses two distinct types of ovarian stem cells: the anteriorly located germline stem cells (GSCs), which give rise to oocytes; and the mid-posteriorly located follicle stem cells (FSCs), which give rise to the somatic follicle cells that cover a developing oocyte. The maintenance and proliferation of GSCs and FSCs is regulated by the stem cell niches, whereas differentiation of the germline is regulated by the differentiation niche. Four distinct Wnt ligands are localized in the germarium, and we focus review on how these Wnt ligands and Wnt signaling affects maintenance and differentiation of both germline and follicle stem cells in their respective niches. View Full-Text
Keywords: Wnt; oocyte; follicle cell; escort cell; cap cell; differentiation niche; long-range signaling; stem cell niche Wnt; oocyte; follicle cell; escort cell; cap cell; differentiation niche; long-range signaling; stem cell niche
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Waghmare, I.; Page-McCaw, A. Wnt Signaling in Stem Cell Maintenance and Differentiation in the Drosophila Germarium. Genes 2018, 9, 127.

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